GRM3 Antibody
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中文名稱：GRM3兔多克隆抗體
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貨號：CSB-PA203777
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規格：￥2024
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圖片：
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Western blot analysis of extracts from mouse brain, using GluR2/3 antibody. -
Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR2/3 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GRM3 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human GluR2/3.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
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基因功能參考文獻：
- experiments indicate that mGlu3Delta4 may negatively modulate mGlu3, and thereby impact on the roles of GRM3/mGlu3 in schizophrenia and as a therapeutic target PMID: 28655286
- Our findings support the GWAS-implicated link between GRM3 genetic variation and schizophrenia risk as well as the notion that alleles conferring this risk may be population specific. PMID: 28786982
- Results demonstrate that GRM3 expression is significantly upregulated in human colonic adenocarcinomas and colon cancer cell lines. This upregulation is mediated at the post-transcriptional level where miR-487b directly targets GRM3 to suppress its translation. Also, the fact that TGFbeta increases GRM3 protein stability provide novel mechanisms of post-transcriptional regulation of GRM3 in colon cancer. PMID: 28114282
- Low GRM3 expression is associated with multiple myeloma and B-cell leukemia. PMID: 27431857
- Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients. PMID: 26187343
- Results show that GRM3 rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype PMID: 25914064
- Grm3 expression was decreased in B cells from patients with autoimmune diseases such as activated systemic lupus erythematosus and multiple sclerosis. PMID: 26071318
- Pharmacogenetic relationships were identified in patients with schizophrenia between GRM3 variants and symptom response to antipsychotics. PMID: 25096017
- PI4KA and GRM3 polymorphisms have potential to jointly modulate antipsychotic response PMID: 25209194
- The mGluR3 promoted the proliferation of human embryonic cortical NPCs and increased cyclin D1 expression by activating ERK1/2 and JNK2 signaling pathways. PMID: 25198581
- The data of this study suggest an association of the GRM3 rs6465084 polymorphism with changes in pursuit maintenance after antipsychotic treatment. PMID: 24682224
- This study provided that the evidence for an association between GRM3 genotype and schizophrenia and suggest a role for glutamate neurotransmission in the establishment and maintenance of myelinated fibers. PMID: 24680030
- results supplied the first evidence that the polymorphism of GRM3 gene associates with the morbidity of alcohol dependence in human beings. PMID: 24585043
- report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production PMID: 24291464
- Data indicate that metabotropic glutamate receptor subtype 3 (mGluR3) polymorphisms do not contribute to genetic susceptibility to schizophrenia and depression, but they confer an increased risk of heroin dependence (HD) in a Chinese population. PMID: 24498053
- The transcript of mGlu3 receptors should be measured in tumor specimens for a correct prediction of patients' survival in response to temozolomide treatment. PMID: 23175182
- Kozak sequence variant associated with bipolar disorder PMID: 23575746
- glutamate system dysfunction may play a role in the prefrontal functional abnormalities seen in alcoholism. certain GRM3 SNP genotypes may further lower NAA/Cr levels and executive function in addition to the effect of alcohol. PMID: 22909248
- Polymorphisms in the GRM3 gene may be associated with refractory global psychosis symptoms but not negative symptoms in persons with schizophrenia. PMID: 21344500
- analysis suggested that mGluR3 is the major mGlu receptor expressed by adult cortical astrocytes, whereas the expression of other mGluRs was low or absent PMID: 23307741
- These results suggest that variations in GRM3 genotype modulate the auditory cortical response to phoneme change in humans. PMID: 22022368
- Melanoma cells expressing mutant GRM3 had reduced cell growth and cellular migration after short hairpin RNA-mediated knockdown of GRM3 or treatment with a selective MEK inhibitor, AZD-6244, which is currently being used in phase 2 clinical trials PMID: 21946352
- This study suggested a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia. PMID: 20638435
- Findings strongly suggest that the genetic variation (rs17676277 and three haplotypes) in the metabotropic glutamate receptor 3is related to cognitive setshifting in healthy individuals independent of working memory. PMID: 20132315
- An association is found between one marker (rs6465084) in glutamate receptor gene GRM3 and Japanese patients with major depressive disorder. PMID: 19386277
- results define a microenvironment within the binding pocket that encompasses several positively charged amino acids that recognize the negatively charged phosphonate group of l-AP4 or the endogenous compound l-serine-O-phosphate. PMID: 11744707
- genetic variation in the metabotropic glutamate receptor 3 gene that might contribute to genetic predisposition to schizophrenia and/or bipolar affective disorder PMID: 11840505
- At least one susceptibility locus for schizophrenia is situated within or very close to the GRM3 region in Japanese patients. PMID: 12782962
- mGluR3 and mGluR5 can critically and differentially modulate the expression of glutamate transporters and may represent interesting pharmacological targets to regulate the extracellular levels of glutamate in pathological conditions. PMID: 12786977
- glial progenitor cells present in the adult human CNS express mGluR3 and mGluR5a PMID: 15158450
- definition of the essential requirements for ligand binding to the extracellular domain of mGluR3 and highlight parameters important for the optimization of receptor expression in mammalian cells PMID: 15178451
- Reduction of mGluR3 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus. PMID: 15246118
- Data point to a specific molecular pathway by which metabotropic glutamate receptor GRM3 alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia. PMID: 15310849
- MGluR3 modulate the release of IL-6 in the presence of IL-1beta, supporting the role of mGluR3 in the regulation of the inflammatory and immune response associated with gliosis. PMID: 15652990
- GRM3 polymorphism may be associated with negative symptom improvement in persons with schizophrenia treated with olanzapine. PMID: 15913960
- The existence of the GRM3Delta4 isoform is relevant in the light of the reported association of non-coding single nucleotide polymorphisms (SNPs) in GRM3 with schizophrenia. PMID: 16417579
- SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT. PMID: 17006672
- mGlu3 receptor levels are altered in schizophrenia PMID: 17531207
- extend putative brain dopaminergic and glutamatergic relationships indexed by catechol-O-methyltransferase and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia PMID: 17636131
- we genotyped rs274622 in the promoter region of GRM3. In the present study, none of these polymorphisms were associated with schizophrenia PMID: 17948896
- Single nucleotide polymorphisms are not assoiated with schziphrenia. PMID: 18075480
- The study of DNA sequence variants in the GRM3 gene did not provide further support for genetic association with schizophrenia or for correlation with cognitive deficits. PMID: 18197082
- An exon 3 single nucleotide polymorphism (SNP) in GRM3 predicts increased splicing of the fourth exon and may contribute to risk for schizophrenia by modulating GRM3 splicing. PMID: 18256595
- The results of the present study indicate that the rs6465084 functional polymorphism in GRM3 does not contribute to genetic susceptibility to schizophrenia. PMID: 18412850
- these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of schizophrenia--REVIEW PMID: 18541626
- Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia. PMID: 18614340
- These data suggest that Glutamate receptor metabotropic 3 glutamate metabotropic receptor is disrupted in the AH in schizophrenia and localize the defect to the CA1 and CA3 regions. PMID: 19403271
- present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia PMID: 19439994
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 3 family
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組織特異性：Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
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