GRM2 Antibody
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中文名稱：GRM2兔多克隆抗體
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貨號：CSB-PA009020
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：AMPA selective glutamate receptor 2 antibody; GLUR2 antibody; GLURB antibody; Glutamate metabotropic receptor 2 antibody; Glutamate receptor homolog antibody; Glutamate receptor metabotropic 2 antibody; GPRC1B antibody; GRM2 antibody; GRM2_HUMAN antibody; Metabotropic glutamate receptor 2 antibody; mGlu2 antibody; mGluR2 antibody; OTTHUMP00000210984 antibody; OTTHUMP00000210986 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human mGluR2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
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基因功能參考文獻(xiàn)：
- mGlu2 receptors can play an influential role in reducing the probability of glutamate neurotransmitter release and potentially effect seizure activity. PMID: 29360159
- Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins. PMID: 28392297
- The present data demonstrateD that a mechanism of group II mGluR-induced analgesia identified in rodent sensory neurons translates mechanistically to human sensory neurons PMID: 27218869
- this work offers new insights into the functioning of the mGlu2 receptor, which might contribute to the development of new and improved PAMs PMID: 26589404
- Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. PMID: 26758213
- Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators. PMID: 25571949
- Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia PMID: 24949866
- Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density PMID: 25150943
- Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects PMID: 23407939
- Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A. PMID: 23129762
- the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration. PMID: 22870276
- Only full-length dimeric mGlu2 activates G protein upon glutamate binding. PMID: 22988116
- Suggest a genetic association exists between SNPs in several genes, such as HTR2A and NRG1, and response to mGlu2/3 agonist LY2140023 treatment in schizophrenia. PMID: 21173788
- data support the idea that glutamate release in the vental tegmental area(VTA) is critically involved in cocaine-induced reinstatement; loss of mGluR2/3-mediated regulation of glutamate release in the VTA may critically contribute to the risk of relapse PMID: 21881873
- Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population PMID: 20211215
- No association is detected between GRM2 and major depressive disorder or bipolar disorder in an allele/genotype-wise or haplotype-wise analysis of Japanese patients. PMID: 19386277
- Mapped to Chromosome 3p21.1 - p21.2 and has 5 exons ranging from 74 - 1076 bp. PMID: 11840499
- The presynaptic group 2 metabotropic glutamate receptor reduces stimulated and spontaneous transmitter release in the dentate gyrus. PMID: 11897108
- Reduction of mGluR2 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus. PMID: 15246118
- Stimulation of glial mGluR2 through mediators present in the cerebrospinal fluid may contribute to glial proliferation and astrogliosis in amyotrophic lateral sclerosis. PMID: 15330338
- Authors have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. PMID: 15837331
- In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis PMID: 18297054
- The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia. PMID: 18853337
- findings show that the activation of mGluR2 leads to the activation of extracellular signal-related kinase pathways PMID: 19026996
- The glutamate receptor metabotropic 2 mutants with increased structural flexibility at this position, which is crucial for pocket closure, were clearly preferred. PMID: 19402024
- The objective of this study was to assess the effects of the mGlu2/3 receptor agonist LY404039 (LY) on operant EtOH self-administration during alcohol seeking pavlovian spontaneous recovery, alcohol relapse, and maintenance responding for alcohol. PMID: 16678921
- Ser-148 and Arg-183 may be important for the 3D structure and/or are involved in closure of the domain. Asp-146 is involved in differential binding properties of mGlur2. PMID: 11641422
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
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蛋白家族：G-protein coupled receptor 3 family
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組織特異性：Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
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數(shù)據(jù)庫鏈接：
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