GREM2 Antibody

說明書

中文名稱：

GREM2兔多克隆抗體
貨號：

CSB-PA107590
規格：

￥1090
圖片：
Western blot analysis of Mouse kidney, 293T, Mouse lung, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9H772
基因名：

GREM2
別名：

BMP antagonist 2 antibody; CKTSF1B2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 2 antibody; DAN domain family member 3 antibody; DAND 3 antibody; DAND3 antibody; GREM 2 antibody; Grem2 antibody; GREM2_HUMAN antibody; Gremlin 2 antibody; Gremlin 2 cysteine knot superfamily homolog antibody; Gremlin-2 antibody; Gremlin2 antibody; PRDC antibody; Protein related to DAN and cerberus antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide from Human protein at AA range: 71-120
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
基因功能參考文獻：
1. TT genotype of the rs4454537 polymorphism protective against the development of osteoporosis PMID: 30014930
2. Our study confirmed that GREM2 is a candidate gene for tooth agenesis, which mutations can explain, however, only a small fraction of the genetic contribution to the pathogenesis of this anomaly. PMID: 28992378
3. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes. PMID: 28125926
4. The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition. PMID: 27524626
5. This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2/Smad/Runx2 pathway. PMID: 27335248
6. The present study shows that the Grem2 heparin/HS and BMP2-binding epitopes are unique and independent, where the Grem2-BMP2 complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope. PMID: 28104757
7. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/beta-catenin signaling PMID: 26239165
8. mutations associated with tooth malformations PMID: 26416033
9. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation. PMID: 25443231
10. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis. PMID: 23902946
11. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development. PMID: 23223679
12. and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk. PMID: 23437003
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相關疾?。?/div>
Tooth agenesis, selective, 9 (STHAG9)
亞細胞定位：

Secreted.
蛋白家族：

DAN family
數據庫鏈接：

HGNC: 17655

OMIM: 608832

KEGG: hsa:64388

STRING: 9606.ENSP00000318650

UniGene: Hs.98206

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