GNAT1 Antibody

中文名稱：

GNAT1兔多克隆抗體
貨號：

CSB-PA009598LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse liver tissue
All lanes: GNAT1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA009598LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA009598LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GNAT1 Polyclonal antibody
Uniprot No.：

P11488
基因名：

GNAT1
別名：

CSNBAD3 antibody; GBT1 antibody; GNAT1 antibody; GNAT1_HUMAN antibody; GNATR antibody; guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 1 antibody; guanine nucleotide binding protein G(T) alpha 1 subunit antibody; Guanine nucleotide-binding protein G(t) subunit alpha-1 antibody; Rod specific transducin antibody; rod-type transducin alpha subunit antibody; Transducin alpha-1 chain antibody; transducin; rod-specific antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-1 protein (92-170AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GNAT1 Antibody (CSB-PA009598LA01HU)，的標記方式是Non-conjugated。對于GNAT1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009598LB01HU	GNAT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009598LC01HU	GNAT1 Antibody, FITC conjugated
Biotin	CSB-PA009598LD01HU	GNAT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase.
基因功能參考文獻：
1. Our family's ERG showed essentially no rod response, consistent with a Danish GNAT1 pedigree but different from the Nougaret GNAT1 pedigree that shows partial preservation of rod signal. A genetic connection between Complete congenital stationary night blindness and postural orthostatic tachycardia syndrome would be intriguing, but we found no evidence for this. PMID: 30051303
2. These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously. PMID: 26472407
3. Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
4. These data suggest that a homozygous missense mutation in GNAT1 is associated with autosomal recessive stationary night blindness. PMID: 22190596
5. Expression of GNAT1 gene is down-regulated or absent in nasopharyngeal carcinoma tissues. PMID: 17222360
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相關疾病：

Night blindness, congenital stationary, autosomal dominant 3 (CSNBAD3); Night blindness, congenital stationary, 1G (CSNB1G)
亞細胞定位：

Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein. Photoreceptor inner segment.
蛋白家族：

G-alpha family, G(i/o/t/z) subfamily
組織特異性：

Rod photoreceptor cells. Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium.
數據庫鏈接：

HGNC: 4393

OMIM: 139330

KEGG: hsa:2779

STRING: 9606.ENSP00000232461

UniGene: Hs.517978

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