GMDS Antibody

中文名稱：

GMDS兔多克隆抗體
貨號：

CSB-PA009569LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA009569LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA009569LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GMDS Polyclonal antibody
Uniprot No.：

O60547
基因名：

GMDS
別名：

GDP D mannose dehydratase antibody; GDP mannose 4 6 dehydratase antibody; GDP-D-mannose dehydratase antibody; GDP-mannose 4,6 dehydratase antibody; GMD antibody; Gmds antibody; GMDS_HUMAN antibody; OTTHUMP00000017756 antibody; OTTHUMP00000232770 antibody; SDR3E1 antibody; Short chain dehydrogenase/reductase family 3E member 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GDP-mannose 4,6 dehydratase protein (243-346AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GMDS Antibody (CSB-PA009569LA01HU)，的標記方式是Non-conjugated。對于GMDS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009569LB01HU	GMDS Antibody, HRP conjugated	ELISA
FITC	CSB-PA009569LC01HU	GMDS Antibody, FITC conjugated
Biotin	CSB-PA009569LD01HU	GMDS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
基因功能參考文獻：
1. Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1), within actin filament associated protein 1 (AFAP1) and within GDP-mannose 46-dehydratase (GMDS). PMID: 25173105
2. These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer. PMID: 23922970
3. Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
4. GMD inhibits tankyrase 1 poly(ADP-ribose) polymerase activity in vitro, dependent on the GMD tankyrase 1 binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1, dependent on the catalytic PARP activity of tankyrase 1. PMID: 22645305
5. Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors. PMID: 22027835
6. FX takes part in the cascade of events leading to the extravasation of activated lymphocytes. PMID: 11831876
7. Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling. PMID: 19361506
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蛋白家族：

NAD(P)-dependent epimerase/dehydratase family, GDP-mannose 4,6-dehydratase subfamily
數據庫鏈接：

HGNC: 4369

OMIM: 602884

KEGG: hsa:2762

STRING: 9606.ENSP00000370194

UniGene: Hs.144496

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