GM2A Antibody, FITC conjugated
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中文名稱：GM2A兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA02375C0Rb
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GM2A Polyclonal antibody
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Uniprot No.：
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基因名：GM2A
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別名：Cerebroside sulfate activator protein antibody; ganglioside GM2 activator antibody; Ganglioside GM2 activator isoform short antibody; Ganglioside GM2 activator precursor antibody; GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2 ganglioside activator protein antibody; GM2-AP antibody; GM2A antibody; GM2AP antibody; OTTHUMP00000160619 antibody; SAP 3 antibody; SAP-3 antibody; SAP3 antibody; SAP3_HUMAN antibody; Shingolipid activator protein 3 antibody; Sphingolipid activator protein 3 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Ganglioside GM2 activator protein (32-193AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
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基因功能參考文獻：
- Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant. PMID: 27402091
- Studies indicate that sphingolipid activator proteins (SAPs) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation. PMID: 27157270
- this study has established the potential role of GM2A in breast cancer progression PMID: 27002480
- Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies PMID: 26175473
- Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
- In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 ganglioside. PMID: 23483939
- impact of GM2AP on glucose metabolism PMID: 21784073
- Treatment of meniscal explants with IL-1RA inhibited the expression of many catabolic genes following a single bout of high dynamic strain. PMID: 21331553
- these results provide novel insights into the physiological functions of GM2AP in obesity. PMID: 21036149
- GM2 activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D PMID: 12576516
- Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket PMID: 12909021
- elucidation of mode of action on gangioside GM2 PMID: 14728689
- alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A PMID: 15485660
- glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk PMID: 17215249
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相關(guān)疾病：GM2-gangliosidosis AB (GM2GAB)
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亞細胞定位：Lysosome.
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數(shù)據(jù)庫鏈接：
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