GLTP Antibody
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中文名稱：GLTP兔多克隆抗體
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貨號(hào)：CSB-PA009539GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：GLTP
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別名：GLTP antibody; GLTP_HUMAN antibody; Glycolipid transfer protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human GLTP
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
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基因功能參考文獻(xiàn)：
- GLTP was specifically labeled by either XLA or XLB GlcCer cross-linker during this process, together with a (the same) small subset of microsomal proteins. These cross-linkers will serve to probe physiologically relevant GlcCer-interacting cellular proteins PMID: 27412675
- GLTP not only could be a significant player in cellular sphingolipid metabolism, but also could have a much broader role in the overall lipid metabolism. PMID: 24824606
- GLTP mediates non-vesicular transport of ganglioside GM1 between native membranes PMID: 23555818
- Comprehensive analysis of the dimerization interfaces discloses -helices 6 and 2 and the protein C-terminus (C-end) as three specific structural elements that are simultaneously involved in dimer formation and ligand binding by GLTP. PMID: 23519669
- findings represent the first known phenotypic changes triggered by GLTP overexpression and regulated by direct interaction with a p120-catenin protein family member PMID: 21625605
- This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide PMID: 20974858
- remarkable versatility for Trp, providing three distinct intramolecular functions in the novel amphitropic GLTP fold PMID: 20959104
- First insights into human GLTP structural dynamics by fluorescence spectroscopy, including global conformational changes that accompany GLTP folding into an active conformational state. PMID: 15287756
- crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology PMID: 15329726
- The rate-limiting step for glycolipid transfer protein (GLTP) action appears to be the surface processes leading to the GLTP-glycosphingolipid complex formation and release associated with a shuttle/carrier mode of action. PMID: 15504043
- analysis of the liganding site in human glycolipid transfer protein PMID: 15901739
- GLTP is not likely involved in the de novo synthesis of glycosphingolipids, but could rather have a role as a glycolipid sensor for the cellular levels of glucosylceramide. PMID: 17980653
- Active transcription was found for 12q24.11 GLTP but 11p15.1 GLTP was transcriptionally silent. PMID: 18261224
- transgenic expression in Arabidopsis thaliana of human GLTP partially suppressed the phenotype of the acd11 null mutant, resulting in delayed programmed cell death development and plant survival PMID: 18657186
- Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: insights into glycolipid binding affinity. PMID: 19270338
- GLTP and VAP-A were shown to interact. PMID: 19665998
- A single-copy 5-exon/4-intron GLTP gene at 12q24.11 was the highly conserved, transcript source of active GLTP in human and vertebrate cells. An intronless GLTP gene at 11p15.1 was transcriptionally silent, primate-specific, and yielded inactive protein. PMID: 18261224
- The paper describes the complete primary amino acid sequence of glycolipid transfer protein (GLTP) from porcine brain. The sequence was determined by Edman degradation. PMID: 2190982
- This paper shows that the rate at which glycolipid transfer protein catalyzes the intermembrane transfer of glycolipids is greatly diminished by increasing the charged lipid content of membranes. PMID: 10653652
- This paper describes the first cloning of the cDNAs encoding the glycolipid transfer proteins of bovine and porcine brain. The cDNAs are highly homologous to the human cDNA (AF209704). PMID: 10671554
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：GLTP family
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組織特異性：Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.
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數(shù)據(jù)庫(kù)鏈接：
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