GFPT1 Antibody
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中文名稱：GFPT1兔多克隆抗體
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貨號：CSB-PA009377GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：GFPT1
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別名：CMS12 antibody; CMSTA1 antibody; D-fructose-6-phosphate amidotransferase 1 antibody; GFA antibody; GFAT 1 antibody; GFAT antibody; GFAT1 antibody; GFAT1m antibody; GFPT antibody; Gfpt1 antibody; GFPT1_HUMAN antibody; GFPT1L antibody; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 antibody; Glutamine--fructose-6-phosphate transaminase 1 antibody; Glutamine:fructose 6 phosphate amidotransferase 1 antibody; Hexosephosphate aminotransferase 1 antibody; MSLG antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human GFPT1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
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基因功能參考文獻：
- high GFAT1 expression is identified as an independent predictor of adverse clinical outcome in our small number of pancreatic cancer patients, and the practical prognostic nomogram model may help clinicians in decision making and the design of clinical studies. PMID: 27996048
- study reports nine new mutations of GFPT1 in limb-girdle congenital myasthenic syndrome (LG-CMS) PMID: 28712002
- Findings indicate that GFAT1 functions as a novel suppressor of EMT and tumor metastasis in gastric cancer. PMID: 27509259
- GNPDA1 siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increased GFAT1, and GFAT1 siRNA increased the expression of hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulated GNPDA1 and GDPDA2, and inhibited cell migration. PMID: 26887390
- High GFAT1 expression is associated with hepatocellular carcinoma. PMID: 28186970
- mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1, and is essential for proper expression and nuclear accumulation of the GFAT1 transcriptional regulator, Xbp1s. PMID: 27570073
- GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. PMID: 28008135
- The AMPK-GFAT1 signaling axis serves as an important communication point between two nutrient-sensitive signaling pathways and is likely to play a significant role in controlling physiological processes in many other tissues. PMID: 28336748
- Increased GFPT1 expression is associated with triple-negative breast cancer. PMID: 26715276
- This study demonstrated that Congenital myasthenic syndrome with tubular aggregates caused by GFPT1 mutations. PMID: 21975507
- 3'-UTR mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome PMID: 25765662
- Two GFPT1 untranslated mutations may cause limb-girdle myasthenia by reducing GFPT1 expression and ultimately impairing protein glycosylation. PMID: 23488891
- Mapping of the regulatory site of glucosamine-6P synthase identified critical residues necessary for catalysis. PMID: 24075873
- Inhibition of GFPT1 enzymatic activity or siRNA silencing of GFPT1 expression resulted in reduced AChR expression. PMID: 23569079
- The results found no correlation between end plate morphology and physiology or between genotype and phenotype in GFPT1-myasthenia. PMID: 23794683
- GFPT1 is the key enzyme in the hexosamine biosynthesis pathway. Mutations in GFPT1 cause defective glycosylation in the proteins of the neuromuscular junction. PMID: 22987706
- Downregulation of the GFPT1 is associated with neuromuscular transmission defect. PMID: 21310273
- An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin PMID: 12802498
- Genetic variation in GFPT1 is unlikely to have a major impact on susceptibility to diabetic nephropathy. PMID: 14988277
- Variants in the GFPT1 gene show suggestive evidence of an association with diabetic nephropathy among African-American individuals, and increased GFPT1 gene expression may characterize Caucasian subjects with diabetic nephropathy. PMID: 15308130
- On the basis of the docking results, a binding pocket of human GFAT1 dimer for UDP-GlcNAc is defined. PMID: 15595739
- two polymorphisms in the 5'-flanking region of GFAT, of which the -913 polymorphism seems to alter the risk for obesity and intramyocellular lipid accumulation in male subjects. PMID: 15613432
- A novel single nucleotide polymorphism identified at position -1412 (G to C) had a functional effect on promoter activity and EMSA revealed specific binding of nuclear proteins to this region. PMID: 15878746
- Testing for association of an +36T>C polymorphism in the glutamine: fructose-6-phosphate amidotransferase 1 gene and type 2 diabetes in Japanese and Caucasians. PMID: 17024311
- These findings suggest for the first time that hGfat1 may be regulated by kinases other than PKA. PMID: 17941647
- The first structures of the isomerase domain of the human GFAT in the presence of cyclic glucose-6-phosphate and linear glucosamine-6-phosphate was reported. PMID: 19059404
- The phosphorylation of GFAT1 at Ser243 by AMPK has an important role in the regulation of the GFAT1 enzymatic activity. PMID: 19170765
- A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle. PMID: 11679416
- expression profiles of GFAT1 mRNA in various human tissues using reverse transcriptase-polymerase chain reaction. The identification and cDNA cloning of a novel GFAT1 splice variant expressed abundantly in skeletal muscle and heart is reported. PMID: 11587069
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相關疾病：Myasthenic syndrome, congenital, 12 (CMS12)
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組織特異性：Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.
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