GFM2 Antibody

說明書

中文名稱：

GFM2兔多克隆抗體
貨號：

CSB-PA924833
規格：

￥2024
圖片：
Western blot analysis of extracts from LOVO cells and RAW264.7cells, using GFM2 antibody.

Immunofluorescence analysis of A549 cells, using GFM2 antibody.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GFM2 Polyclonal antibody
Uniprot No.：

Q969S9
基因名：

GFM2
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human GFM2.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
基因功能參考文獻：
1. GFM2 mutations could be causative of a phenotype of Leigh syndrome with arthrogryposis multiplex congenita. PMID: 26016410
2. These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans PMID: 22719265
3. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2. PMID: 18753147
4. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. PMID: 19716793
亞細胞定位：

Mitochondrion.
蛋白家族：

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 29682

OMIM: 606544

KEGG: hsa:84340

STRING: 9606.ENSP00000296805

UniGene: Hs.277154

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