GFI1 Antibody
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中文名稱：GFI1兔多克隆抗體
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貨號：CSB-PA009371GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：GFI1
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別名：GFI 1 antibody; GFI1 antibody; GFI1_HUMAN antibody; Growth factor independence 1 antibody; Growth factor independent 1 antibody; Growth factor independent protein 1 antibody; SCN2 antibody; Zinc finger protein 163 antibody; Zinc finger protein Gfi 1 antibody; Zinc finger protein Gfi-1 antibody; Zinc finger protein Gfi1 antibody; ZNF 163 antibody; ZNF163 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human GFI1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
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基因功能參考文獻：
- GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. PMID: 29651020
- High GFI1 expression is associated with Acute myeloid leukemia. PMID: 28574132
- Differential methylation was observed in the CYP1A1 promoter and AHRR gene body regions between women who smoked throughout pregnancy and non-smokers on the fetal-side of the placenta and in the GFI1 promoter between women who quit smoking while pregnant and non-smokers on the maternal-side of the placenta PMID: 28820654
- GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. PMID: 28387757
- Simvastatin attenuates the tumor-associated macrophage mediated gemcitabine resistance of PDAC by blocking the TGF-beta1/Gfi-1 axis. PMID: 27840243
- combination of the sequence-specific and nonspecific DNA-binding modes of SATB1 should be advantageous in a search for target loci during transcriptional regulation PMID: 27480105
- GFI1(36S) homozygous patients exhibited a sustained response to treatment with hypomethylating agents, whereas GFI1(36N) patients had a poor sustained response to this therapy. Because allele status of GFI1(36N) is readily determined using basic molecular techniques, we propose inclusion of GFI1(36N) status in future prospective studies for MDS patients to better predict prognosis and guide therapeutic decisions. PMID: 27080012
- Maternal-smoking sensitive CpG sites in newborns were significantly associated with cg18146737 SNP located proximal to GFI1. PMID: 27403598
- In this study, the influence of prenatal smoking exposure on the childrens' DNA methylation state of a CpG island located upstream of the promoter of the growth factor independent 1 (GFI1) gene was analyzed. Significant hypomethylation was observed in this CpG island in SIDS cases with cigarette smoke exposure compared to non-exposed cases. PMID: 27677632
- Gfi1 gene expression is regulated by cytokines in activated T cells. PMID: 27143377
- miR-495 directly interacts with the Gfi1 3'UTR to regulate Gfi1 at a post-transcriptional level and the expression level of miR-495 is inversely correlated with the Gfi1 protein level in medulloblastoma specimens. PMID: 26160036
- Gfi1 acts as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations of the C-terminal zinc finger domain causes congenital neutropenia. It may be involved in leukemia and lymphoma. Review. PMID: 26447191
- During infection, the incoming HCMV rapidly downregulates the GFI1 mRNA and protein in both wild-type cells and in cells in which EZH2, NDY1/KDM2B or JARID2 were knocked down. PMID: 24830456
- Data shows that MYB regulates the expression of endogenous human GFI1. PMID: 24121275
- results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer PMID: 25043047
- Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1. PMID: 24198842
- GFI1 is repressed by p53 PMID: 24023884
- the expression of Gfi-1 contributes to SOCS1 silencing in AML cells through epigenetic modification, and suppression of histone methyltransferase can provide new insight in AML therapy. PMID: 24018353
- Studies indicate that Gfi1 recruits LSD1 to p53 and dampens its activity by de-methylating p53 at C-terminal lysines to prevent immediate apoptosis. PMID: 23528269
- The competition for this binding site inhibits the expression of HOXA9 and induces different transcriptional outcomes, which suggests a new direction for investigation of the mechanism underlying targeted therapy of malignant gliomas. PMID: 23466061
- Our data suggest that the presence of a GFI136N variant allele induces a preleukemic state in myeloid precursors by deregulating the expression of Hoxa9 and other AML-related genes. PMID: 22932805
- Data suggest that Gfi1 may have an important role in prolonged multiple myeloma (MM)-induced osteoblast (OB) suppression and provide a new therapeutic target for MM bone disease. PMID: 22042697
- GFI1 may play an important role in leukemia, especially in CML incidence and progression. PMID: 20723283
- GFI-1 expression is upregulated in leukemia patients and may contribute to leukemogenesis. PMID: 20723286
- Studies indicate that Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or malignant hematopoiesis. PMID: 20571393
- An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed. PMID: 20087403
- a variant allele of GFI1 (GFI1(36N)) is associated with acute myeloid leukemia (AML) in white subjects PMID: 20075157
- Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2 PMID: 12778173
- role for auto- and trans-regulation of Gfi1 by GFI1 and GFI1B in maintaining the normal expression patterns of Gfi1 PMID: 15131254
- GFI1 in prostate cancer cells acts as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase gene. PMID: 15947108
- findings highlight the role of epigenetics in the regulation of development and oncogenesis by Gfi1 PMID: 16287849
- Gfi1 levels are regulated by the ubiquitin-proteasome system. It binds the promoters of several granulocyte-specific genes in primary monocytes. This correlated with low expression of these genes in monocytes compared with granulocytes. PMID: 16888099
- GFI1 may play a significant role in the down regulation of endogenous production of 1,25D in prostate cancer cells and could provide a novel insight to future diagnosis and treatment PMID: 17207994
- Decreased Gfi-1 levels in our SGD patient, together with the mutant C/EBPepsilon, block secondary granules proteins expression, thereby contributing to the underlying etiology of the disease in our patient. PMID: 17244686
- Results identify PRDM5, which acts as a sequence-specific, DNA binding transcription factor that targets hematopoiesis-associated protein-coding and microRNA genes, some of which are targets of Gfi1. PMID: 17636019
- The fine-tuning of Gfi1 protein levels regulated by Triad1 defines an unexpected role for this protein in hematopoiesis. PMID: 17646546
- The measurement of CD34 and GFI1 mRNA expressions could be useful as a diagnostic and prognostic marker for myelodysplastic syndrome. PMID: 18371060
- Ajuba is utilized as a corepressor selectively on Gfi1 target genes PMID: 18805794
- These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth. PMID: 19026687
- data reveal a mechanism of transcriptional repression by Gfi-1 and may have important implications for understanding the roles of Gfi-1 in normal development and tumorigenesis PMID: 19164764
- Data suggest that expression of PFAAP5 allows neutrophil elastase to potentiate the repression of Gfi1 target genes. PMID: 19506020
- Gfi1 mRNA level in both the mononuclear cells and purified CD34(+) cells from CML were significantly higher as measured by quantitative real-time PCR. PMID: 19887785
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相關疾病：Neutropenia, severe congenital 2, autosomal dominant (SCN2); Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA)
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亞細胞定位：Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
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