GALR1 Antibody

說明書

中文名稱：

GALR1兔多克隆抗體
貨號：

CSB-PA008578
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P47211
基因名：

GALR1
別名：

GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human GALR1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
基因功能參考文獻：
1. High methylation of GALR1 is associated with head and neck cancer. PMID: 27027429
2. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
3. The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder PMID: 28007761
4. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
5. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID: 24706871
6. GALR1 methylation is associated with endometrial cancer. PMID: 23727823
7. Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . PMID: 22859720
8. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. PMID: 21796100
9. The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. PMID: 21430647
10. it has been demonstrated that GalR1-5-HT1A receptors heteromerize. PMID: 20171159
11. disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation PMID: 15767248
12. The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents. PMID: 15930442
13. There was no effect of GALR1 on alcoholism risk. PMID: 17083333
14. Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. PMID: 17982695
15. GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO PMID: 18385373
16. GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. PMID: 18973137
17. GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma PMID: 19047085
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

HGNC: 4132

OMIM: 600377

KEGG: hsa:2587

STRING: 9606.ENSP00000299727

UniGene: Hs.272191

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