GABRD Antibody

說明書

產品詳情

Uniprot No.：

O14764
基因名：

GABRD
別名：

GABA(A) receptor subunit delta antibody; Gabrd antibody; Gamma aminobutyric acid GABA A receptor delta antibody; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody; Gamma-aminobutyric acid receptor subunit delta antibody; GBRD_HUMAN antibody; MGC45284 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human GABRD
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
基因功能參考文獻：
1. This study found that increased methylation of the promoter of the delta subunit GABAA receptor was associated with reduced mRNA and protein levels in the cerebellum of alcohol use disorder subjects. PMID: 29020412
2. Genome-wide association studies identify GABRD mutation releated to juvenile myoclonic epilepsy PMID: 23756480
3. In recombinant human cDNA experiments in HEK293 cells, delta subunit coexpression leads to receptors activated by nanomolar THIP concentrations. PMID: 21795619
4. These findings point to the GABRD gene as a susceptibility gene for COMD. PMID: 20561060
相關疾病：

Generalized epilepsy with febrile seizures plus 5 (GEFS+5); Epilepsy, idiopathic generalized 10 (EIG10); Juvenile myoclonic epilepsy 7 (EJM7)
亞細胞定位：

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRD sub-subfamily
數據庫鏈接：

HGNC: 4084

OMIM: 137163

KEGG: hsa:2563

STRING: 9606.ENSP00000367848

UniGene: Hs.113882

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