FXYD5 Antibody
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中文名稱：FXYD5兔多克隆抗體
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貨號：CSB-PA009093GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：FXYD5
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別名：FXYD5 antibody; DYSAD antibody; IWU1 antibody; HSPC113 antibody; UNQ2561/PRO6241FXYD domain-containing ion transport regulator 5 antibody; Dysadherin antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human FXYD5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
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基因功能參考文獻：
- the ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion. PMID: 27142834
- Knockdown of FXYD5 in MDA-MB-231 breast cancer cells largely decreases expression and secretion of the chemokine CCL2 (MCP-1). A related effect has also been observed in renal cell carcinoma cells. PMID: 27006401
- Study demonstrated that the expression of FXYD1, FXYD3 and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients PMID: 26410457
- Dysadherin-silenced side population cells exhibited reduced expression of Bcl-2 and Bax compared with that prior to silencing. PMID: 26458963
- we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer PMID: 22105147
- Findings suggest that dysadherin might contribute to breast cancer progression through AKT activation. PMID: 22494103
- These results suggest a role of let-7a down-regulation in the development of thyroid neoplasias of the follicular histotype, likely regulating dysadherin protein expression levels. PMID: 22965940
- Data show that osteoblasts are the major cell type of the bone marrow that affect RCC cells by secreting factors that increase the expression of dysadherin and CCL2 in the tumor cells leading to enhanced cell migration. PMID: 21328336
- This is the first report on expression of dysadherin in the male gonad and in spermatozoa. PMID: 21774927
- Overexpression of Snail, Slug, and dysadherin and activation of Wnt and PI3K/Akt signaling was associated with inactivated E-cadherin in the spindle cells of monophasic fibrous synovial sarcomas. PMID: 21809991
- Combined dysadherin-positive expression and E-cadherin-negative expression may be valuable information for predicting aggressive tumor behavior of differentiated-type gastric carcinoma with submucosal invasion PMID: 21239043
- transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of cencer stem cells, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo PMID: 20952084
- In lung carcinomas dysadherin expression seems to reflect tumour aggressiveness and may be considered a positive marker of poor prognosis when considered alone or/and in combination with down-regulation of E-cadherin. PMID: 20712010
- The detection of dysadherin in tumors and cytokeratin in the lymph nodes may be a potential significant indicator of a poor prognosis for patients who undergo complete resection of stage I non-small cell lung cancer PMID: 20944097
- We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. PMID: 11756660
- dysadherin expression was significantly associated with the prognosis, occurrence of secondary undifferentiated carcinomas, size of the primary tumor, and metastasis to the regional lymph nodes and lungs PMID: 12970317
- dysadherin has a role in hematogenous metastasis of gastric cancer PMID: 15102690
- Dysadherin and E-cadherin expression may help to predict the prognosis of patients with ESCC (esophageal squamous cell carcinoma). PMID: 15459499
- Dysadherin is able to modulate actin structures, stimulate cell motility, and contribute directly to the metastatic potential of human pancreatic cancer cells. PMID: 15466191
- dysadherin may be a valuable prognostic marker in cervical carcinoma. PMID: 15619642
- Over expression of dysadherin is associated with cutaneous malignant melanoma PMID: 15751018
- In testicular tumours, as in other neoplasms, dysadherin downregulates E-cadherin expression, at least in part PMID: 16333245
- Found in trophoblasts in both normal and abnormal pregnancies. PMID: 17084448
- Dysadherin may play an important role in breast cancer progression by promoting invasion. PMID: 17437014
- Recent work that has provided insights into possible mechanisms of action of dysadherin in the cancer progression process was reviewed. PMID: 17442482
- FXYD5 is upregulated in cystic fibrosis epithelia which may exacerbate the Na(+) hyperabsorption and surface liquid dehydration observed in cystic fibrosis. PMID: 18263667
- Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia PMID: 18677652
- The dysadherin expression level was significantly correlated with gastrointestinal stromal tumor risk stratification. PMID: 19217217
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：FXYD family
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數據庫鏈接：
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