FRS3 Antibody

說明書

產品詳情

Uniprot No.：

O43559
基因名：

FRS3
別名：

FRS3Fibroblast growth factor receptor substrate 3 antibody; FGFR substrate 3 antibody; FGFR-signaling adaptor SNT2 antibody; Suc1-associated neurotrophic factor target 2 antibody; SNT-2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human FRS3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
基因功能參考文獻：
1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor. PMID: 20228838
2. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings PMID: 23279575
3. FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors PMID: 11877385
4. FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts PMID: 15094036
5. SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2 PMID: 15485655
6. Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2. PMID: 16702953
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亞細胞定位：

Membrane; Lipid-anchor.
數據庫鏈接：

HGNC: 16970

OMIM: 607744

KEGG: hsa:10817

STRING: 9606.ENSP00000259748

UniGene: Hs.194208

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