FRMD5 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FRMD5 Polyclonal antibody
Uniprot No.：

Q7Z6J6
基因名：

FRMD5
別名：

FRMD5; FERM domain-containing protein 5
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human FERM domain-containing protein 5 protein (295-504AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.
基因功能參考文獻：
1. We conclude that integrative variants, haplotypes and diplotypes of the CAPN3 rs4344713 and FRMD5 rs524908, as well as DBP and BMI are associated with serum lipid variables in the Jing and Han populations. PMID: 28332615
2. Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells. PMID: 28117551
3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
4. FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression PMID: 22846708
亞細胞定位：

Membrane; Single-pass membrane protein. Cell junction, adherens junction.
數據庫鏈接：

HGNC: 28214

OMIM: 616309

KEGG: hsa:84978

STRING: 9606.ENSP00000403067

UniGene: Hs.578544

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