FOXD1 Antibody

說明書

中文名稱：

FOXD1兔多克隆抗體
貨號：

CSB-PA291867
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA291867(FOXD1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q16676
基因名：

FOXD1
別名：

Brain Factor 2 antibody; FKH L8 antibody; FKHL 8 antibody; FKHL8 antibody; Forkhead (Drosophila) like 8 antibody; Forkhead box D1 antibody; Forkhead box protein D1 antibody; Forkhead drosophila homolog like 8 antibody; Forkhead like 8 antibody; Forkhead related activator 4 antibody; Forkhead related protein FKHL8 antibody; Forkhead related transcription factor 4 antibody; Forkhead-related protein FKHL8 antibody; Forkhead-related transcription factor 4 antibody; FOX D1 antibody; FOXD 1 antibody; foxd1 antibody; FOXD1_HUMAN antibody; FREAC 4 antibody; FREAC-4 antibody; FREAC4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human FOXD1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:500-1:5000
IHC	1:10-1:50

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells. Involved in transcriptional activation of PGF and C3 genes.
基因功能參考文獻：
1. as well as stemness abilities but stronger senescence and higher apoptosis rate. CONCLUSION: We found that overexpression of miR-338-5p suppresses glioma cell proliferation, migration, and invasion and accelerates its senescence and apoptosis by decreasing FOXD1 expression via inhibition of activation of MAPK-signaling pathway. PMID: 30225541
2. FOXD1 is overexpressed in osteosarcoma while MiR-30a-5p is lowexpressed. MiR-30a-5p directly regulates FOXD1 by binding its 3'-UTR. PMID: 29936179
3. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
4. FOXD1 promoted the expression of Plk2 mRNA and protein in colorectal cancer cells. PMID: 29864920
5. Results showed that FOXD1 is a major actor in mammalian reproduction as sequence variants generated recurrent spontaneous abortion (RSA) and embryonic resorption (ER). Data propose that the FOXD1-p.429AlaAla mutation might be used as an RSA molecular marker while FOXD1 p.Ala88Gly variant might have a protective effect. PMID: 27805902
6. our findings define a FOXD1-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors PMID: 27569208
7. The role of FOXD1 in glioma tumorigenesis, migration and progression.High FOXD1 expression in glioma. PMID: 28075458
8. FOXD1 promotes breast cancer proliferation and chemotherapeutic drug resistance by targeting p27 PMID: 25462566
9. Lung cancer patients with high FOXD1 expression survive for a significantly shorter time than those with low FOXD1 expression. PMID: 25550559
10. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production PMID: 24099863
11. the level of Smad6s can alter the level of TGF-beta and the subsequent induction of PAI-1 via a FoxD1 transcription site PMID: 15716278
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 3802

OMIM: 601091

KEGG: hsa:2297

STRING: 9606.ENSP00000462795

UniGene: Hs.519385

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