FOXA2 Antibody
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中文名稱：FOXA2兔多克隆抗體
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貨號：CSB-PA146585
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規格：￥2024
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圖片：
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Western blot analysis of extracts from 293, HT29, HepG2 cells using FoxA2(HNF3b) Antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) FOXA2 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human
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免疫原：Peptide sequence around aa.435~439( A-S-P-L-A) derived from Human FoxA2(HNF3b).
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
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基因功能參考文獻：
- might be a progesterone-induced gene, which may participate in the 'metastatic' process of eutopic endometrium to ectopic loci in patients with endometriosis PMID: 29233503
- FOXA2 may act as a tumor suppressor and inhibit the epithelial-mesenchymal transition of endometrial cancer cells. PMID: 29442045
- Our findings suggest that autophagy, through participation of FOXA2, maintains the characteristics of OCSCs. Autophagy and FOXA2 are therefore potential targets for ovarian cancer stem cell directed therapies. PMID: 29187221
- MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia. PMID: 29200841
- In conclusion, our data suggest that overexpression of the Hedgehog components SHH, GLI2 and FOXA2 might be used as markers of an aggressive hemangioma. PMID: 28370639
- Our results suggest that FoxA2 plays a key role in the expression of hepatic phenotype of AFP-producing adenocarcinomas. PMID: 28778497
- FOXA2 is a specific and sensitive molecular marker for small cell neuroendocrine carcinoma of the prostate. PMID: 28621319
- HNF3beta plays a vital role in regulation of CPS1 gene and could promote the metabolism of ammonia by regulating CPS1 expression. PMID: 28272778
- The c.505T>C, p.S169P genetic variant occurs at the conserved forkhead DNA binding domain of the FOXA2 and causes a rare and unique clinical phenotype of hypopituitarism, CHI, dysmorphic features, liver, pancreas, heart and gastrointestinal abnormalities. PMID: 28973288
- Results showed that FOXA2 expression was decreased during Il-13 induced goblet cell differentiation but DNA methylation of its promoter was not changed. In the absence of Il-13, no difference was found for FOXA2 expression but hypomethylation of CpG # 10 and 11 in the its promoter was detected. These findings suggest that aberrant DNA methylation of FOXA2 is one of the factors underlying mucus hypersecretion in COPD. PMID: 28450970
- the findings of the current study provide compelling genetic evidence that FOXA2 is a pathogenic driver gene in the etiology of primary uterine cancers, including uterine carcinosarcomas and carcinomas. PMID: 28940304
- Physical and functional interactions between LXRalpha and FOXA2 were established in vitro and ex vivo. PMID: 28576574
- SIRT1 directly interacts with and deacetylates Foxa2 to inhibit its transcriptional activity on expression of genes involved in bile acids synthesis and transport. PMID: 27816442
- Iotansulin decreased LPL mRNA levels in HepG2 cells and this was associated with phosphorylation of AKT and nuclear export of FOXA2. PMID: 28126606
- findings provide the structural basis for FOXA2 protein binding to a consensus forkhead site and elucidate how members of the forkhead protein family bind different DNA sites. PMID: 28644006
- Low FOXA2 expression is associated with metastasis of gastric cancer. PMID: 28098868
- FOXA2 identified as a novel tumor suppressor in pancreatic cancer. It is regulated directly by miR-199a. PMID: 27151939
- This study used combined immunohistochemical staining for a marker of hepatic commitment and specification (FOXA2 [Forkhead box A2]), hepatocyte maturation (Albumin and HepPar1), and features of bile ducts (CK19 [cytokeratin 19]) to identify lineages of stem cells differentiating toward the hepatocytic or bile ductular compartments of end-stage cirrhotic human liver. PMID: 27879410
- Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas. PMID: 28188614
- The pattern of FOXA2 mutations and expression in tumors suggests complex regulation and a haploinsufficient or dominant-negative tumor suppressor function. PMID: 27538367
- Study demonstrated downregulation of expression of pancreatic master genes SOX9, FOXA2, and GATA4 (2-, 5-, and 4-fold, respectively) and in PANC1 pancreatic cancer cell line stimulated with TGFbeta1 PMID: 27599506
- The definitive endoderm and foregut endoderm differentiation capabilities of Wnt pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 and those of the transcription activator GATA4 and the alpha-fetoprotein (AFP) gene, respectively. PMID: 26861571
- Our results suggest that FOXA2 promotes cell proliferation, maintains cancer stem cells, favors the development of Triple-Negative/Basal-like tumors, and is associated with increase relapses. PMID: 26298189
- FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells. PMID: 25921584
- we propose that haploinsufficiency for FOXA2 combined with a decreased expression of NODAL is the likely cause for syndromic BA in this proband. PMID: 25765999
- DEANR1 facilitates FOXA2 activation by facilitating SMAD2/3 recruitment to the FOXA2 promoter PMID: 25843708
- Expression of FOXA2 is reduced in gastric adenocarcinoma tissues and its low-expression is correlated with malignant clinical pathological features PMID: 25940296
- results provide opportunities to understand the FOXA2-centered transcriptional regulation network and novel therapeutic targets to modulate this network in p53-deficient lung cancer PMID: 26093302
- FOXA2 as a core transcriptional modulator for pulmonary xenobiotic metabolic pathways; regulates pulmonary expression of CYP2A13 and ABCB1 PMID: 25667220
- Results show that miR-141 functions as a tumor suppressor in hepatocellular carcinoma cells through the inhibition of HNF-3beta translation. PMID: 25425543
- Study confirmed that FOXA2 inhibited EMT in breast cancer cells by regulating the transcription of EMT-related genes such as E-cadherin and ZEB2. PMID: 25779673
- identification of transcription factors specific to early mesoderm commitment; FOXA2 observed to be the most significantly differentially expressed at human embryonic stem cell-endothelial cell day 2; FOXA2 transcription start site is marked with histone modifications for gene activation and repression PMID: 23618383
- Results suggest that FOXA2 induced the differentiation of gastric cancer and highlight FOXA2 as a novel therapeutic tartet and prognostic marker for human gastric cancer. PMID: 25129104
- we proved that FOXA2 repressed the transcription of matrix metalloproteinase (MMP)-9 and exerted its antimetastasis effect partially through downregulation of MMP-9. PMID: 25142974
- this study demonstrates that SIRT1 controls the acetylation level of FOXA2 in a nutrient-dependent manner and in times of nutrient shortage the interaction between SIRT1 and FOXA2 is reduced. PMID: 24875183
- Collectively, these studies demonstrated that Mycoplasma pneumoniae induces airway mucus hypersecretion by modulating the STAT/EGFR-FOXA2 signaling pathways. PMID: 25287927
- results suggest a novel and unexpected role for DNA methylation in the activation of FoxA2 gene expression during differentiation PMID: 25016019
- FOXA2 is acting as a master regulator of key pathways that are enriched for loci implicated by GWAS for most trait categories, with the clear exception of inflammation, suggesting that this factor exerts its effect via noninflammatory processes. PMID: 24878043
- Respiratory epithelial cells express FOXA2 during different stages of lung development. PMID: 24970044
- Knockdown of FoxO1 and ectopic expression of FoxA2 significantly decreased hepatitis C virus replication. PMID: 24478438
- our study indicates that beta-catenin regulates Foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation PMID: 22945641
- Upregulation of Foxa2 expression can enhance cIAP1, which inhibits the hepatocyte apoptosis. PMID: 23275033
- epigenetic silencing of Foxa2 is associated with an increased DNA methylation level and histone H4 (Lys-20) trimethylation, decreased histone H3 acetylation and histone H3 (Lys-4) trimethylation, involved in cellular replicative or premature senescence. PMID: 23391216
- VEGF may first downregulate expression of Foxa2 by enhancing Nur77 activity PMID: 22877565
- These findings suggest that Foxa2 negatively regulates the basal transcription and expression of the human FTO gene. PMID: 23236435
- Human Foxa2 efficiently promoted the incorporation of mesenchymal stem cells into damaged liver tissues. PMID: 22432472
- The main mechanism of downregulation of Foxa2 is epigenetic silencing through promoter hypermethylation PMID: 22341411
- FOXA2 rs1209523 was not significantly associated with fasting plasma glucose in glucose-tolerant individuals from the general Danish population of middle-aged people PMID: 22325233
- These results suggest that increased sensitivity of the polymorphic matrix metalloproteinase 7 promoter to FOXA2 provides one of the genetic bases for the upregulation of matrix metalloproteinase 7 in idiopathic pulmonary fibrosis. PMID: 22268124
- pFOXA2 expression is positively correlated with IKKalpha and activated NOTCH1 expression in tumor tissues. PMID: 22196886
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亞細胞定位：Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
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