FOSB Antibody
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中文名稱：FOSB兔多克隆抗體
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貨號：CSB-PA960251
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA960251(FOSB Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Activator protein 1 antibody; AP 1 antibody; DKFZp686C0818 antibody; FBJ murine osteosarcoma viral oncogene homolog B antibody; fosB antibody; FOSB_HUMAN antibody; G0/G1 switch regulatory protein 3 antibody; G0S3 antibody; GOS 3 antibody; GOS B antibody; GOS3 antibody; GOSB antibody; MGC42291 antibody; Oncogene FOS B antibody; Oncogene FOSB antibody; Protein fos B antibody; Protein fosB antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human FOSB
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：FosB interacts with Jun proteins enhancing their DNA binding activity.
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基因功能參考文獻：
- miR-144-3p plays an important role in pancreatic cancer cell proliferation, migration, and invasion by targeting FOSB PMID: 28653602
- FOSB immunohistochemistry is sensitive in the diagnosis of angiolymphoid hyperplasia with eosinophilia, and allows differentiation from its histological mimics PMID: 29527734
- FOSB overexpression results in TNBC cell death, whereas inhibition of calcium signaling eliminates FOSB induction and blocks TP4-induced TNBC cell death PMID: 27248170
- results shows the involvement of Spry2 in regulation of FosB and Runx2 genes, MAPK signaling and proliferation of mesenchymal stem cells. PMID: 28387432
- the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
- The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID: 28724635
- FosB expression in the prefrontal cortex and hippocampus of the cocaine addicted and depression patients PMID: 27494187
- FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma. PMID: 28009608
- our findings show that DeltaFosB increases the expression of MMP-9 and exhibits a significantly high survival and proliferation in MCF-7 cells. PMID: 26608367
- Diffuse and strong FOSB expression was specific for pseudomyogenic hemangioendothelioma in the current series and FOSB immunohistochemistry is an effective tool for differentiating between PHE and its histological mimics. PMID: 27515856
- Our results using a number of approaches, such as promoter reporter assay, FosB knock down and Chip assay, suggest that the expression of miR-22 is regulated transcriptionally by FosB. PMID: 27889568
- These results suggest that SETDB1- mediated FosB expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy. PMID: 26949019
- studies of FosB are providing new insight into the molecular basis of depression and antidepressant action. PMID: 25446562
- The abnormalities were screened by FISH in 44 epithelioid hemangioma (EH) from different locations with seven additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. PMID: 25043949
- This study describing the expres-sion pattern of FosB/ FosB immunoreactivity inpost mortem basal ganglia sections from Parkinson disease patients. PMID: 23933656
- Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
- Data indicate a significant correlation in miR-181b, FOS and miR-21 expression glioma tissues. PMID: 23810250
- Report Fos-B expression in skin keratinocytes/fibroblasts and keloid fibroblasts exposed to genistein. PMID: 23614275
- AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription. PMID: 21543584
- Induction of a DeltaFOSB mediated transcriptional pattern in the prefrontal cortex is opposite to the down-regulation observed in the nucleus accumbens in patients with major depressive disorder PMID: 21616539
- Findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases. PMID: 20826776
- transcription factor FosB/activating protein-1 (AP-1) activation is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells PMID: 20813842
- RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
- demonstrated that a functional AP-1 site mediates MMP-2 transcription in cardiac cells through the binding of distinctive Fra1-JunB and FosB-JunB heterodimers. The synthesis of MMP-2 is considered to be independent of the AP-1 transcriptional complex PMID: 12371906
- AP-1 (c-Jun & FosB) binds to a site in the 5' untranslated region of the CD95L gene. Transdominant negative Jun mutants reduce CD95L promoter activity. FosB dimerized with c-Jun has an important role in TCR/CD3-mediated activation-induced cell death. PMID: 12618758
- In hepatoma-associated anorexia-cachexia FpsB was induced in several brain areas of thes forebrain. PMID: 15926923
- activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11 PMID: 18490653
- DeltaFosB was able to trigger partial Pref-1-mediated de-differentiation of adipocytes, which also retained their adipocytic cell phenotype. PMID: 18491952
- An IFN-gamma-mediated homeostatic loop limits the potential for tissue damage associated with inflammation and identifies transcriptional factor AP-1 that regulates matrix metalloproteinase expression in myeloid cells in inflammatory settings. PMID: 18802113
- MicroRNA-101, which is aberrantly expressed in hepatocellular carcinoma, could repress the expression of the FOS oncogene. PMID: 19133651
- FosB is induced in PMA treated K562 cells in a sustained manner and forms an active AP-1 protein-DNA complex. Down-regulation of FosB with specific shRNAs inhibited the induction of CD41, a specific cell surface marker of megakaryocytes. PMID: 19381435
- Results suggest that in addition to clinically prognostic factors, FOS-B expression has a debatable impact on patient survival. PMID: 19795327
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亞細胞定位：Nucleus.
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蛋白家族：BZIP family, Fos subfamily
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數據庫鏈接：
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