FKBP6 Antibody

中文名稱：

FKBP6兔多克隆抗體
貨號：

CSB-PA008702LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA008702LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008702LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA008702LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: HEK293 whole cell lysate
All lanes: FKBP6 antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 37, 34 kDa
Observed band size: 38 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FKBP6 Polyclonal antibody
Uniprot No.：

O75344
基因名：

FKBP6
別名：

36 kDa FK506 binding protein antibody; 36 kDa FK506-binding protein antibody; 36 kDa FKBP antibody; EC 5.2.1.8 antibody; FK506 binding protein 6 antibody; FK506-binding protein 6 antibody; FKBP 36 antibody; FKBP-36 antibody; FKBP-6 antibody; FKBP36 antibody; fkbp6 antibody; FKBP6_HUMAN antibody; Immunophilin FKBP36 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP6 antibody; PPIase antibody; PPIase FKBP6 antibody; Rotamase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inactive peptidyl-prolyl cis-trans isomerase FKBP6 protein (101-327AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FKBP6 Antibody (CSB-PA008702LA01HU)，的標記方式是Non-conjugated。對于FKBP6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA008702LB01HU	FKBP6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008702LC01HU	FKBP6 Antibody, FITC conjugated
Biotin	CSB-PA008702LD01HU	FKBP6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
基因功能參考文獻：
1. Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80). PMID: 24241165
2. 278A polymorphism of FKBP6 gene was associated with idiopathic azoospermia, while C/T, 370G/A, 430G/C, 467T/C, 468G/A polymorphisms might be very rare in Chinese population. PMID: 15696470
3. may play a role in modifying the susceptibility to idiopathic spermatogenic impairment in human; allele A of c.216C>A seems to be a protective factor for the development of male infertility PMID: 17307919
4. clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats PMID: 18529014
5. FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH PMID: 19001379
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相關疾病：

FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).
亞細胞定位：

Cytoplasm, cytosol. Nucleus. Chromosome.
蛋白家族：

FKBP6 family
組織特異性：

Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
數據庫鏈接：

HGNC: 3722

OMIM: 604839

KEGG: hsa:8468

STRING: 9606.ENSP00000252037

UniGene: Hs.661266

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