FGR Antibody

中文名稱：

FGR兔多克隆抗體
貨號：

CSB-PA008655LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA008655LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA008655LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA008655LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) FGR Polyclonal antibody
Uniprot No.：

P09769
基因名：

FGR
別名：

c fgr antibody; c fgr protooncogene antibody; c src 2 proto oncogene antibody; c src2 antibody; Fgr antibody; FGR_HUMAN antibody; FLJ43153 antibody; Gardner Rasheed feline sarcoma viral (v fgr) antibody; Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody; MGC75096 antibody; p55 c fgr protein antibody; P55 FGR antibody; P55-FGR antibody; p55c fgr antibody; p58-Fgr antibody; p58c fgr antibody; p58c-Fgr antibody; Proto oncogene c Fgr antibody; Proto oncogene tyrosine protein kinase FGR antibody; Proto-oncogene c-Fgr antibody; SRC 2 antibody; SRC2 antibody; Tyrosine protein kinase Fgr antibody; Tyrosine-protein kinase Fgr antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Tyrosine-protein kinase Fgr protein (11-72AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，F(xiàn)GR Antibody (CSB-PA008655LA01HU)，的標(biāo)記方式是Non-conjugated。對于FGR Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA008655LB01HU	FGR Antibody, HRP conjugated	ELISA
FITC	CSB-PA008655LC01HU	FGR Antibody, FITC conjugated
Biotin	CSB-PA008655LD01HU	FGR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production.
基因功能參考文獻(xiàn)：
1. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival. PMID: 28585144
2. the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance. PMID: 27324824
3. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. PMID: 25972488
4. Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells. PMID: 23896410
5. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target PMID: 21300758
6. Substitution of two relevant serines with glutamic acid residues in urokinase prevents urokinase activation of p55fgr needed for cell migration and adhesion. PMID: 11928806
7. Recruitment of the coactivator, SRC2, is coupled to cooperative DNA binding by the progesterone receptor. PMID: 17845055
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相關(guān)疾病：

Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
亞細(xì)胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
組織特異性：

Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
數(shù)據(jù)庫鏈接：

HGNC: 3697

OMIM: 164940

KEGG: hsa:2268

STRING: 9606.ENSP00000363115

UniGene: Hs.1422

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