FGF13 Antibody

中文名稱：

FGF13兔多克隆抗體
貨號：

CSB-PA008619LA01HU
規格：

￥440
圖片：
Western blot
All lanes: FGF13 antibody at 12µg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 22, 29, 23, 26 kDa
Observed band size: 28 kDa

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA008619LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA008619LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA008619LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FGF13 Polyclonal antibody
Uniprot No.：

Q92913
基因名：

FGF13
別名：

FGF 13 antibody; FGF 2 antibody; FGF-13 antibody; FGF13 antibody; FGF13_HUMAN antibody; FGF2 antibody; FHF 2 antibody; FHF-2 antibody; FHF2 antibody; Fibroblast growth factor 13 antibody; Fibroblast growth factor homologous factor 2 antibody; OTTHUMP00000024143 antibody; OTTHUMP00000024144 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Fibroblast growth factor 13 protein (1-245AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FGF13 Antibody (CSB-PA008619LA01HU)，的標記方式是Non-conjugated。對于FGF13 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA008619LB01HU	FGF13 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008619LC01HU	FGF13 Antibody, FITC conjugated
Biotin	CSB-PA008619LD01HU	FGF13 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.
基因功能參考文獻：
1. The present study reported the presence of FGF13 in the follicular fluid of women undergoing IVF/ICSI. Moreover, the relationships between FF-FGF13 and FF-TT, ovarian morphology and oocyte developmental competence imply that FF-FGF13 might be involved in the pathophysiological process of polycystic ovary syndrome. PMID: 30257687
2. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
3. FGF13 was downregulated in human placentae with early-onset preeclampsia. FGF13 played an important role in maintaining placental trophoblast permeability via the modulation of E-cadherin. PMID: 29405966
4. We propose that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell. Thus, FGF13 may serve as an enabler, allowing cancer cells to evade proteostasis stress triggered by oncogene activation. PMID: 27994142
5. Study screened the coding and splice site regions of the FGF13 gene in a sample of 45 unrelated probands where genetic epilepsy with febrile seizures plus segregated in an X-linked pattern; subsequently identified a de novo FGF13 missense variant in an additional patient with febrile seizures and facial edema. Results suggest that FGF13 is not a common cause of genetic epilepsy with febrile seizures plus. PMID: 27810516
6. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
7. These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 channel modulation and suggested the importance of isoform-specific regulation PMID: 27246624
8. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
9. for PCa patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR-free survival, in particular if combined with other clinical parameters. PMID: 26891277
10. The findings of this study reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability. PMID: 26063919
11. X-chromosome deletions may be a cause of WS with larger deletions being lethal to males and that FGF13 mutations may be a cause of Wildervanck Syndrome (WS). PMID: 23373430
12. Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells PMID: 24113164
13. FGF13 has a role in hair follicle growth and in the hair cycle as shown in a family with X-linked congenital generalized hypertrichosis PMID: 23603273
14. interactions with perlecans PMID: 11847221
15. identification of a domain controlling angiogenic properties PMID: 12496262
16. FHF2B is an interacting partner of Na(v)1.6. The preferential expression of FHF2B in sensory neurons may provide a basis for physiological differences in sodium currents that have been reported at the nodes of Ranvier in sensory versus motor axons. PMID: 15282281
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亞細胞定位：

Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Cytoplasm. Nucleus.
蛋白家族：

Heparin-binding growth factors family
組織特異性：

Ubiquitously expressed. Predominantly expressed in the nervous system.
數據庫鏈接：

HGNC: 3670

OMIM: 300070

KEGG: hsa:2258

STRING: 9606.ENSP00000359635

UniGene: Hs.6540

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