FBXO10 Antibody, FITC conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) FBXO10 Polyclonal antibody
Uniprot No.：

Q9UK96
基因名：

FBXO10
別名：

F box protein 10 antibody; F-box only protein 10 antibody; FBX10 antibody; FBX10_HUMAN antibody; Fbxo10 antibody; hCG_2011110 antibody; PRMT11 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human F-box only protein 10 protein (248-400AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
基因功能參考文獻：
1. siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not. PMID: 26187670
2. Higher Fbxo10 expression in T cells is associated with Mcs5a increased susceptibility alleles PMID: 23138933
3. FBXO10, a protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. PMID: 23431138
相關(guān)疾病：

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.
亞細胞定位：

Cytoplasm.
數(shù)據(jù)庫鏈接：

HGNC: 13589

OMIM: 609092

KEGG: hsa:26267

STRING: 9606.ENSP00000403802

UniGene: Hs.709527

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