FAT4 Antibody

中文名稱：

FAT4兔多克隆抗體
貨號(hào)：

CSB-PA017577
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA017577(FAT4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA017577(FAT4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q6V0I7
基因名：

FAT4
別名：

Cadherin family member 14 antibody; Cadherin related family member 11 antibody; CDHF14 antibody; CDHR11 antibody; FAT atypical cadherin 4 antibody; FAT J antibody; FAT tumor suppressor homolog 4 antibody; Fat-like cadherin protein FAT-J antibody; FAT4 antibody; FAT4_HUMAN antibody; FATJ antibody; hFat4 antibody; HKLLS2 antibody; Nbla00548 antibody; Protocadherin Fat 4 antibody; Putative protein product of Nbla00548 antibody; VMLDS2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthetic peptide of Human FAT4
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
基因功能參考文獻(xiàn)：
1. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
2. Study shows that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1-FAT4 mutations, functional cerebral asymmetries are stronger. PMID: 25930014
3. Epigenetic inactivation of FAT4 contributes to gastric field cancerization. PMID: 26792292
4. In hepatocellular carcinoma patients, both FAT4 expression and FAT4 mutational status significantly correlated with patient prognosis. FAT4 acts as a putative tumor suppressor that is frequently inactivated in human hepatocellular carcinoma. PMID: 26672766
5. In conclusion, Fat4 expression is deceased in gastric cancer cells, leading to nuclear translocation of Yap and correlates with poor prognosis. PMID: 26575609
6. FAT4 has a tumour suppressor role mediated by the modulation of Wnt/beta-catenin signalling, providing potential novel targets for the treatment of gastric cancer PMID: 26633557
7. our results reveal a novel inhibitory mechanism of FAT4 gene expression through actin depolymerization during Src-induced carcinogenesis in human breast cells. PMID: 25679223
8. These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2+)-binding amino acids from specific EC-EC linkers, and can therefore adapt to confined spaces. PMID: 25355906
9. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. PMID: 24349473
10. Homozygosity mapping and whole-exome sequencing was used in the original Hennekam syndrome family with multiple affected individuals in whom no CCBE1 mutation had been detected, and identified a homozygous mutation in the FAT4 gene. PMID: 24913602
11. findings show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia PMID: 24056717
12. The atypical cadherin Fat4 encodes at least part of the stromal cell differentiation signal. PMID: 23974041
13. the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility PMID: 23319386
14. Recurrent somatic mutations in FAT4 gene is associated with gastric adenocarcinoma. PMID: 22484628
15. Fat4 may be a breast tumor suppressor gene PMID: 19048595
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相關(guān)疾病：

Van Maldergem syndrome 2 (VMLDS2); Hennekam lymphangiectasia-lymphedema syndrome 2 (HKLLS2)
亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 23109

OMIM: 612411

KEGG: hsa:79633

STRING: 9606.ENSP00000377862

UniGene: Hs.563205

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