FASLG Antibody

說明書

中文名稱：

FASLG兔多克隆抗體
貨號：

CSB-PA002482
規格：

￥1090
圖片：
Western Blot analysis of 293 cells using FAS-L Polyclonal Antibody

Western Blot analysis of HepG2 cells using FAS-L Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P48023
基因名：

FASLG
別名：

ALPS1B antibody; Apoptosis (APO 1) antigen ligand 1 antibody; Apoptosis antigen ligand 1 antibody; Apoptosis antigen ligand antibody; APT1LG1 antibody; APTL antibody; CD178 antibody; CD178 antigen antibody; CD95 ligand antibody; CD95-L antibody; CD95L antibody; CD95L protein antibody; Fas antigen ligand antibody; Fas L antibody; Fas ligand (TNF superfamily member 6) antibody; Fas ligand antibody; FASL antibody; Fasl Fas ligand (TNF superfamily member 6) antibody; FASLG antibody; Generalized lymphoproliferative disease antibody; Gld antibody; soluble form antibody; TNFL6_HUMAN antibody; TNFSF6 antibody; Tumor necrosis factor (ligand) superfamily member 6 antibody; Tumor necrosis factor ligand superfamily member 6 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human FAS-L.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.; Cytoplasmic form induces gene transcription inhibition.
基因功能參考文獻：
1. FASLG single-nucleotide polymorphisms rs763110 and rs5030772 are involved in the pathogenesis of Idiopathic Aplastic Anemia PMID: 29611722
2. Evaluation of FAS/FASL polymorphisms can predict lack of response to BCG immunotherapy and prevent the loss of valuable time before such alternative treatments as early cystectomy are initiated. PMID: 29453645
3. results suggest that miR-21 regulates the apoptosis of keloid fibroblasts via targeting FasL, and caspase-8 and the mitochondria-mediated apoptotic signaling pathway is involved in this process. PMID: 29527928
4. the detailed mechanisms of FasL-Fas necroptosis can help in understanding the processes of elimination of tumor cells that have blocked apoptosis signal transduction PMID: 30103900
5. Increased FASL expression is associated with dermatofibrosarcoma protuberans. PMID: 29509956
6. data demonstrated that FASL-844C/T SNP was substantially associated with idiopathic azoospermia, indicating that it might be a genetic predisposing factor of idiopathic azoospermia in the Western of Iran. PMID: 28942044
7. platelet-derived FasL has a role in apoptosis in stroke PMID: 27608763
8. The Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment response in Crohn's disease and may help select patients likely to benefit from therapy. PMID: 28785150
9. serum levels of soluble FAS ligand (sFASL) and interferon gamma (IFN-gamma) were analyzed and correlated with sFGL2 levels in Hepatitis C Virus-Infected Patients and Hepatocellular Carcinoma Patients. PMID: 28609212
10. Study shows for the first time that CD95L activates NHE1, which thereby enhances cell migration. Using a combination of inhibitors and site-directed mutagenesis, results subsequently demonstrate that this mechanism occurs through a modification of NHE1 cooperative response to intracellular protons and that it involves both the Akt and RhoA-dependent pathways. PMID: 27302366
11. These results suggest that the FasL -844T>C single nucleotide polymorphism is implicated in the susceptibility to hepatitis C virus in Egyptian patients and firstly report the involvement of TRAIL gene polymorphism in the risk of the disease. PMID: 28587866
12. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. PMID: 27682872
13. This study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L. PMID: 28514658
14. FasL -844C>T polymorphism plays a protective role against Head and Neck Cancer development in Asian population. PMID: 29419701
15. The Fas mRNA expression ratio was unchanged upon MTX treatment, but the FasL mRNA expression ratio was significantly higher in MTX-treated than nontreated polyps. In addition, the expression levels of the Fas and FasL proteins were significantly higher in polyps treated with both 10 and 100 muM MTX compared with nontreated polyps. PMID: 28468172
16. Results show that the FasL:Fas complex shares structural features with the FasL:DcR3 assembly and the glycosylation contributes to the activity of soluble FasL PMID: 27806260
17. FASLG c.-844TC genotype may be protective against familial mediterranean fever in the Turkish population. PMID: 28442396
18. The rs763110 TT genotype significantly increased the risk of cervical cancer compared with the CC/CT genotype. Patients carrying this genotype presented a lower cancerous FASL expression than that of the CC/CT genotypes. OCT1 was recruited to the FASL promoter region and regulated the FASL gene transcription by interacting with C/EBPbeta. PMID: 27790710
19. Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. These inductive effects might be via targeting FASLG and activating FADD and caspases. PMID: 28013316
20. FasL gene polymorphism is associated with Hashimoto's thyroiditis. PMID: 27572459
21. There is a positive correlation of the serum level of sFasL ( Fas/FasL axis )with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 expression was positively correlated with sFasL expression PMID: 28326325
22. The results of this study did show an initial decrease in sCD95L, but this was followed by a steady increase above initially measured concentrations. Furthermore, we found that patients with clinically documented neurological remission showed higher sCD95L serum concentrations than patients without remission. PMID: 27089864
23. suppression of EP1 prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels PMID: 26211005
24. In sprint-trained male athletes, FasL, miR-21, and miR-146a were measured cross-sectionally (n = 67, 18-90 yrs) and serum FasL, miR-21, and miR-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n = 49, 50-90 yrs). PMID: 28127562
25. In women with endometriosis, immunostaining for Fas-Ligand in the eutopic endometrium was stronger in the epithelial cells of secretory phase, while the epithelial cells of endometriotic lesions showed a significantly stronger staining for Fas-Ligand independently from the menstrual phase PMID: 26156853
26. The study identified Fas ligand (FASLG) as the target of let-7e-5p, and FASLG knockdown increased the migration and tube formation of endothelial progenitor cell. PMID: 26826505
27. Case Reports: patients with autosomal recessive inheritance of ALPS-FASLG have a severe phenotype and a partial defect in activation-induced cell death in T- and B-cell lines. PMID: 26334989
28. No mutation or variation could be found in FASL in patients or controls. PMID: 26690594
29. FASL, granzyme B, and cytochrome c blood expression reflects breast cancer progression and response to therapy. (Review) PMID: 27117663
30. No association has been found between FASL promoter polymorphisms and predisposition to HIV infection. PMID: 26429326
31. FASL expression is an independent marker for earlier disease relapse and disease-specific death in oral squamous cell carcinoma. PMID: 26400345
32. These data indicate that Epstein-Barr virus exosomes derived from EBV-infected cells are taken up by non-infected cells and induce apoptosis via the extrinsic pathway, and that exosomes trigger apoptosis through the FasL pathway. PMID: 26467838
33. The expression of Ki67 and FasL is closely related to the occurrence and development of cervical carcinoma. PMID: 26345794
34. Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons. PMID: 26582200
35. In patients with either Crohn's disease or ulcerative colitis, the extent of endothelial FasL expression was elevated in the submucosa and associated with an elevated number of lymphoid follicles. PMID: 26374830
36. Th1 cells express high level of FAS-ligand (FASL), which interacts with FAS and leads to caspases' cleavage and ultimately to cell death. PMID: 25950471
37. Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells PMID: 26359460
38. FASL -844 T > C promoter single nucleotide polymorphism is associated with oral cancers. PMID: 25944167
39. Death induced by CD95R/L elimination (DICE) and CD95-mediated apoptosis have opposing roles in eliminating cancer stem cells (CSCs)and non-CSCs. PMID: 25366259
40. Membrane-bound FasL mediates platelets-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces platelets-induced apoptosis. PMID: 26232171
41. DcR3 enhances ERK1/2 phosphorylation and opposes FasL signaling in pancreatic cancer cells PMID: 26102031
42. MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG. PMID: 25394756
43. FasL -844 CC combined with the Fas -1377 G allele is a protective factor against ESCC. PMID: 24473454
44. High Fas expression promotes chemoresistance in gastrointestinal cancer by up-regulating P-glycoprotein. PMID: 25333257
45. There was no correlation between TGF-beta1 levels and HBV load, but there is a positive correlation between sFas levels and HBV load. PMID: 25990938
46. data strongly indicate that the inhibition of ceramide conversion to complex sphingolipids by D609 is accompanied by an enhancement of FasL-induced caspase-dependent and -independent cell death in T lymphocytes. PMID: 22942738
47. during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. PMID: 22942752
48. these findings provide novel experimental evidences supporting that VC or/and VE could reduce p,p'-DDT-induced cytotoxicity of HL-7702 cells via the ROS-mediated mitochondrial pathway and NF-kappaB/FasL pathway. PMID: 25464339
49. Fas ligand correlates with the documented degree of atrial apoptosis and atrial fibrosis in right atrial appendage tissue after cardiac surgery. PMID: 23790081
50. The T/T genotype and the T allele of the c.-844T>C polymorphism were associated with increased occurrence of keratoconus, while the C allele was associated with decreased keratoconus occurrence. PMID: 25169582
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相關疾病：

Autoimmune lymphoproliferative syndrome 1B (ALPS1B)
亞細胞定位：

Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen.; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted.; [FasL intracellular domain]: Nucleus.
蛋白家族：

Tumor necrosis factor family
數據庫鏈接：

HGNC: 11936

OMIM: 134638

KEGG: hsa:356

STRING: 9606.ENSP00000356694

UniGene: Hs.2007

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