FANCI Antibody, HRP conjugated

說明書

中文名稱：

FANCI兔多克隆抗體, HRP偶聯
貨號：

CSB-PA889120LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FANCI Polyclonal antibody
Uniprot No.：

Q9NVI1
基因名：

FANCI
別名：

FANCI antibody; FANCI gene antibody; FANCI_HUMAN antibody; Fanconi anemia group I protein antibody; Fanconi anemia; complementation group I antibody; FLJ10719 antibody; FLJ14658 antibody; KIAA1794 antibody; Protein FACI antibody; Protein FANCI antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Fanconi anemia group I protein (180-252AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
基因功能參考文獻：
1. BRMS1FANCI interaction is necessary for the regulatory role of BRMS1 in the FA pathway. PMID: 30365131
2. Study reports the first structural insight into the human FANCD2-FANCI complex by obtaining the cryo-EM structure. The complex contains an inner cavity, large enough to accommodate a double-stranded DNA helix, as well as a protruding Tower domain. Disease-causing mutations in the Tower domain are observed in several Fanconi anemia patients. PMID: 27405460
3. FANCI phosphorylation activates the FANCI/D2 complex. PMID: 28636932
4. Data suggest that FANCI and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response. PMID: 29059323
5. Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors, such as SF3B1. PMID: 29030393
6. FANCB dimer coordinates FANCD2:FANCI monoubiquitination by two FANCL RING-ligases. Deubiquitination of FANCD2:FANCI by USP1:UAF1 occurs only when DNA is removed. PMID: 27986371
7. depletion of FANCI, but not FANCD2 or USP1, results in increased phosphorylation and activation of Akt. PMID: 27097374
8. FANCI mutations are associated with Fanconi anemia in VACTERL association. PMID: 26590883
9. FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation. PMID: 26336824
10. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2, and alter the current view of the FA-BRCA pathway. PMID: 26430909
11. these purification methods for human FANCI and FANCD2 provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2. PMID: 25168188
12. Results show that ATR-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress. PMID: 25843623
13. Our studies reveal a previously unknown mechanism for the coordinate nuclear import of a subset of FANCD2 and FANCI, a key early step in the cellular ICL response. PMID: 24278431
14. Mutations in FANCI that impair its DNA binding activity compromise DNA-stimulated FANCD2 monoubiquitination. PMID: 24623813
15. A CUE ubiquitin-binding domain in the FANCD2 protein is required for interaction with FANCI, retention of monoubiquitinated FANCD2, and FANCI in chromatin, and for efficient DNA interstrand crosslinks repair. PMID: 22855611
16. These data suggest a key role for the E3 ligase activity of RAD18 in the recruitment of FANCD2 and FANCI to chromatin and the events leading to their ubiquitylation during S phase. PMID: 21355096
17. although proper nuclear localization of FANCI is crucial for robust FANCD2 monoubiquitination, the putative FANCI EDGE motif is important for DNA crosslink repair PMID: 20971953
18. study characterizes FANI which promotes DNA interstrand cross-linking repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the FANCI-FANCD2 complex PMID: 20671156
19. description of the Fanconi anemia protein FANCI, identified as an ATM/ATR kinase substrate required for resistance to mitomycin C; it associates with FANCD2 and, together, as the FANCI-FANCD2 (ID) complex, localizes to chromatin in response to DNA damage PMID: 17412408
20. These data add up to two conclusions. First, KIAA1794 is a Fanconi anemia gene. Second, this gene is identical to FANCI, since the patient cell lines found mutated in this study included the reference cell line for group I, EUFA592. PMID: 17452773
21. FANCI, a member of the Fanconi anemia pathway, is monoubiquitinated in a site-specific and DNA damage dependent manner. PMID: 17460694
22. Results suggest that the multiple phosphorylation of FANCI serves as a molecular switch in activation of the Fanconi anemia pathway. PMID: 18931676
23. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination. PMID: 19111657
24. Data show that FANCD2 and FANCI specifically associate with common fragile site loci irrespective of whether the chromosome is broken, and that these loci are frequently interlinked through BLM-associated ultra-fine DNA bridges through mitosis. PMID: 19465922
25. the FANCI-FANCD2 complex may participate in repair of damaged replication forks through its preferential recognition of branched structures. PMID: 19561358
26. results rule out a major role of FANCI in familial breast cancer susceptibility PMID: 19737859
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相關疾病：

Fanconi anemia complementation group I (FANCI)
亞細胞定位：

Nucleus. Cytoplasm. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
數據庫鏈接：

HGNC: 25568

OMIM: 609053

KEGG: hsa:55215

STRING: 9606.ENSP00000310842

UniGene: Hs.513126

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