F2RL2 Antibody
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中文名稱：F2RL2兔多克隆抗體
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貨號：CSB-PA008165
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：F2RL2; PAR3; Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human PAR-3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IF, ELISA
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推薦稀釋比：
Application Recommended Dilution IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
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基因功能參考文獻：
- PAR3 is essential in thrombin stimulated insulin secretion. PMID: 26742564
- TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. PMID: 26729042
- These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation. PMID: 25320242
- In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav. PMID: 24699825
- Elevated expression of PAR-3, but not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients. PMID: 23739922
- A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects. PMID: 23788139
- PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts. PMID: 22541814
- Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT). PMID: 21596928
- FXa bound in a punctate manner to thrombi under shear, while thrombin and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi PMID: 20454680
- genetic polymorphism is associated with peripheral arterial disease severity PMID: 20390230
- A novel role is identified for PAR3 in thrombin signaling. PMID: 20442298
- Down-regulation of connexin and par-3 signals early anaplasia and malignant change in rectal cancer. PMID: 19513616
- upregulated thrombin generation and inhibition of fibrinolysis, occurred in one-third of the Stem cell transplant patients associating with the development of Graft versus host disease PMID: 19718071
- Lower plasma levels of thrombin-antithrombin complex correlate to higher recanalisation rates after ischaemic stroke PMID: 19806263
- PAR-3 is expressed in human SMC and triggers intracellular calcium signaling. PMID: 14515192
- expression of PAR3 mRNA and protein in cells undergoing megakaryocytic maturation suggests a developmental role for PAR3; regulation of PAR3 expression appears to be specifically coupled to the protein kinase C system. PMID: 15504554
- a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway PMID: 15850610
- The changes in levels of blood coagulation factor ii in folic acid deficient rats are reversed by treatment with folic acid. PMID: 16046705
- F2R genetic variants may influence the natural history of CHD in patients at high risk of cardiovascular events. PMID: 17347481
- PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses PMID: 18264801
- Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. PMID: 18836030
- This study demonstrates that the anticoagulant profile of thrombin often caused by a mutation of the thrombin scaffold finds its likely molecular origin in the stabilization of the inactive E* form. PMID: 19473969
- Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. PMID: 19586901
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
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數據庫鏈接：
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