ENPP1 Antibody
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中文名稱：ENPP1兔多克隆抗體
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貨號：CSB-PA007679GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Alkaline phosphodiesterase 1 antibody; ARHR2 antibody; COLED antibody; E-NPP 1 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase 1 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 antibody; ENPP1 antibody; ENPP1_HUMAN antibody; Ly 41 antigen antibody; M6S1 antibody; Membrane component chromosome 6 surface marker 1 antibody; NPP1 antibody; NPPase antibody; NPPS antibody; Nucleotide pyrophosphatase antibody; PC 1 antibody; PC-1 antibody; PCA1 antibody; PDNP1 antibody; Phosphodiesterase I/nucleotide pyrophosphatase 1 antibody; Plasma cell membrane glycoprotein 1 antibody; Plasma-cell membrane glycoprotein PC-1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ENPP1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect. Appears to modulate insulin sensitivity and function. Also involved in melanogenesis. Also able to hydrolyze 2'-3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production. 2'-3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2'-3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP.
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基因功能參考文獻：
- ENPP1 gene variants may have a potential impact on the occurrence of T2 diabetes mellitus in Northern Iranians. PMID: 29958952
- ENPP1 K121Q polymorphism is associated with type 2 diabetes mellitus in Ukrainian population. In carriers of the minor Q-allele the risk of T2DM is 1.4x higher than in homozygotes in the main K-allele. The risk increases in patients with BMI >/= 25 kg/m2 PMID: 30099416
- this study shows that ENPP1 is biomarker candidate for endometriosis PMID: 29194839
- ENPP1 rs997509 polymorphism is associated with type 2 diabetes mellitus development in Ukrainian population. PMID: 29783211
- This meta-analysis revealed that the K121Q (rs1044498 C > A) in the ENPP1 gene is a risk factor for Coronary Heart Disease. PMID: 29979387
- This study identifies the genetic variant rs9373000 as a potentially causal variant for mandibular condyle geometry variation for patients presenting with dento-facial deformities. PMID: 28381371
- these results show that ENPP1 polymorphism influences lower anterior face height, the distance from the upper lip to the nasal floor, and lip shape PMID: 28415752
- PC-1 works in conjunction with E3 ligase CHIP to regulate androgen receptor stability and activity. PMID: 27835608
- Single nucleotide polymorphism in ENPP1 gene is associated with Gender differences in type 2 diabetes. PMID: 28951309
- Single nucleotide polymorphism in ENPP1 gene is associated with developing of bone disorders in type 2 diabetes. PMID: 28942038
- ENPP1 defines a subset of human B cells that differs significantly from mouse peritoneal B-1a and proposed human B-1 cells. PMID: 27029896
- We have identified TT genotype of SNP rs858339 (ENPP1 gene) as a protective factor against TMD in a population of patients with dentofacial deformities. PMID: 27519661
- Evidence of a causative link between ENPP1 and alterations in insulin signaling, glucose uptake, and lipid metabolism in subcutaneous abdominal Adipose tissue of gestational diabetes, which may mediate insulin resistance and hyperglycemia in Gestational diabetes. PMID: 28080219
- We investigated whether ENPP1 gene which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders before and after orthodontic and orthognathic surgery treatment PMID: 29103441
- Results identified four mutants (p.Tyr471Cys, p.Ser504Arg, p.Tyr659Cys, p.His777Arg) in ENPP1 gene with residual NPP activity, inorganic pyrophosphate generation and plasma membrane localization. PMID: 27467858
- The ENPP1 rs1044498 SNP is associated with T2D. PMID: 27238374
- Results suggest that heterozygous mutations in the SMB domains of ENPP1 are necessary, but not always sufficient in themselves to cause Cole disease. PMID: 26617416
- The K121Q polymorphism of ENPP1 shows no direct correlation with metabolic syndrome in Han Chinese. PMID: 27219689
- Our findings demonstrate that ENPP1, TCF7L2, and FTO may predispose to T2DM in the mixed-ancestry population. PMID: 26958016
- In this exploratory analysis, IRS1, ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes. PMID: 26868433
- we found that patients with severe asthma exacerbation had reduced activity of leukocyte ectonucleotidases and reduced expression of E-NPP1 in PMNs. PMID: 26405014
- A rare type of idiopathic infantile arterial calcification resulting from a mutation in the gene encoding for the ENPP1 enzyme. PMID: 27029882
- Loss of function mutation in ENPP1 is associated with early onset hearing loss in autosomal recessive hypophosphatemic rickets. PMID: 25741938
- ENPP1 was also identified as a substrate of the 26S proteasome, the activity of which is downregulated in CSCs PMID: 26065921
- ENPP1 rs1805101 polymorphism is associated with Insulin resistance and advanced Diabetic nephropathy. PMID: 25594612
- The present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of diabetic kidney disease in European and Asian populations. PMID: 25794151
- the ENPP1 K121Q polymorphism is associated with insulin resistance during web-based lifestyle intervention, and the K121 allele has a beneficial effect of weight loss on insulin resistance. PMID: 25368487
- In pregnant women, association of both pre-gestational BMI and age with AA homozygous ENPP1 genotype increased significantly the risk of positive oral glucose tolerance test. PMID: 25222839
- this study identified only 1 mutation in ENPP1 in the Chinese pseudoxanthoma elasticum population PMID: 25615550
- EphA3 was induced by PC-1 and contributed to the malignant progression of prostate cancer PMID: 25231727
- patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum PMID: 25504209
- Polymorphisms in ALP, ENPP1 and ANKH are important genetic risk factors contributing to Pseudoxanthoma elasticum PMID: 25025693
- findings show the Q allele of the ENPP1 K121Q gene may contribute to the susceptibility for type 2 diabetes in Caucasians and Asians PMID: 25109753
- ENPP1 2'3'-cGAMP-hydrolyzing activity is repsonsible for tumor progression in humans and mice. PMID: 25344812
- these results reveal that E-NPP1, by acting upstream of E2F1, is indispensable for the maintenance of glioblastoma stem-like cells in vitro and hence required to keep GSCs in an undifferentiated, proliferative state. PMID: 24531536
- The mutant homozygous genotype of ENPP! K121Q, was more prevalent in diabetic hypertensive MI patients than it was among non-diabetic normotensive MI patients. PMID: 24242286
- Both NPP1 and NPP3 ectoenzymes are expressed in N2a cells, their levels dramatically changing when cells differentiate into a neuronal-like phenotype PMID: 24947519
- Specific genotypes of the NPP1 gene IVS20-11delT and A533C SNPs may predict ossification of the posterior longitudinal ligament disease outcome after surgical intervention. PMID: 24222241
- The ENPP1 K121Q gene polymorphism is associated with insulin resistance in an obese North Indian population. PMID: 24371178
- ENPP1 (and PLIN) genes contribute to the risk of type 2 diabetes in a Taiwanese population. PMID: 23111648
- The combined studies expand our understanding of NPP1 and NPP4 substrate specificity and range and provide a rational mechanism by which polymorphisms in NPP1 confer stroke resistance. PMID: 24338010
- Biallelic mutations in ENPP1 were shown to underlie a number of recessive conditions characterized by ectopic calcification. PMID: 24075184
- these data suggest a potential role for Enpp1 in the development of breast cancer bone metastasis. PMID: 23861746
- Individuals carrying the ENPP1 Q121 variant are highly responsive to the effect of weight loss on fasting glucose so the Q121 variant interacts with adiposity in modulating glucose homeostasis. PMID: 22402064
- Human phosphodiesterase 1 is regulated by a tandem of N-terminal calmodulin/Ca(2+)-binding domains. PMID: 22484154
- Platelets and serum E-NPP1 activity increased in prostate cancer patients. PMID: 23433854
- mutation in GOLGB1 (Y1212C) and another mutation in ENPP1 (K173Q) were confirmed as having significant associations with a decreased risk for stroke PMID: 23422753
- ENPP1 gene polymorphism rs1409181 was associated with left ventricular hypertrophy in older Chinese people in Guangzhou. PMID: 21162834
- The findings suggest that ENPP1 polymorphisms may contribute to different metabolic characteristics, all of which are associated with insulin resistance in mixed ancestry children of South Africa. PMID: 23451554
- the ENPP-1 Q121 variant plays a role in modulating the risk of premature atherosclerotic events, particularly in obese individuals PMID: 22899099
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相關疾病：Ossification of the posterior longitudinal ligament of the spine (OPLL); Arterial calcification of infancy, generalized, 1 (GACI1); Diabetes mellitus, non-insulin-dependent (NIDDM); Hypophosphatemic rickets, autosomal recessive, 2 (ARHR2); Cole disease (COLED)
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亞細胞定位：[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein.; [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted.
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蛋白家族：Nucleotide pyrophosphatase/phosphodiesterase family
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組織特異性：Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. Expressed in melanocytes but not in keratinocytes.
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