ENPEP Antibody

說(shuō)明書(shū)

中文名稱：

ENPEP兔多克隆抗體
貨號(hào)：

CSB-PA14759A0Rb
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA14759A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA14759A0Rb at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ENPEP Polyclonal antibody
Uniprot No.：

Q07075
基因名：

ENPEP
別名：

Aminopeptidase A antibody; AMPE_HUMAN antibody; AP-A antibody; APA antibody; bp-1 antibody; bp1 antibody; CD249 antibody; Differentiation antigen gp160 antibody; EAP antibody; Enpep antibody; Glutamyl aminopeptidase (aminopeptidase A) antibody; Glutamyl aminopeptidase antibody; Gp160 antibody; Ly51 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Glutamyl aminopeptidase protein (719-949AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，ENPEP Antibody (CSB-PA14759A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于ENPEP Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA14759B0Rb	ENPEP Antibody, HRP conjugated	ELISA
FITC	CSB-PA14759C0Rb	ENPEP Antibody, FITC conjugated
Biotin	CSB-PA14759D0Rb	ENPEP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
基因功能參考文獻(xiàn)：
1. We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner PMID: 28177885
2. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. PMID: 26311161
3. This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms. PMID: 24885240
4. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation PMID: 23888046
5. There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls PMID: 21697726
6. Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes. PMID: 17850355
7. Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II. PMID: 17990103
8. Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. PMID: 17999179
9. Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors. PMID: 18188697
10. rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study PMID: 18206321
11. The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system. PMID: 18410507
12. A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake. PMID: 18550936
13. Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. PMID: 18677709
14. Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production. PMID: 19187443
15. The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue. PMID: 19373777
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亞細(xì)胞定位：

Cell membrane; Single-pass type II membrane protein.
蛋白家族：

Peptidase M1 family
組織特異性：

Expressed in choriocarcinoma cancer cell lines (at protein level). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 3355

OMIM: 138297

KEGG: hsa:2028

STRING: 9606.ENSP00000265162

UniGene: Hs.435765

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