EML1 Antibody

說明書

產品詳情

Uniprot No.：

O00423
基因名：

EML1
別名：

echinoderm microtubule associated protein like 1 antibody; Echinoderm microtubule-associated protein-like 1 antibody; ELP79 antibody; EMAL1_HUMAN antibody; EMAP antibody; EMAP-1 antibody; EMAPL antibody; Eml1 antibody; FLJ45033 antibody; HuEMAP antibody; HuEMAP-1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human EML1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
基因功能參考文獻：
1. a homozygous truncating variant in EML1 is a novel cause of congenital hydrocephalus. PMID: 28556411
2. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region. PMID: 25740311
3. We found EML1 to be mutated in ribbon-like heterotopia in humans PMID: 24859200
4. determined a 2.6-A crystal structure of the representative approximately 70-kDa core of EML1, revealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propeller in EMLs) domain PMID: 24706829
相關疾病：

Band heterotopia (BH)
亞細胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
蛋白家族：

WD repeat EMAP family
組織特異性：

Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
數據庫鏈接：

HGNC: 3330

OMIM: 600348

KEGG: hsa:2009

STRING: 9606.ENSP00000334314

UniGene: Hs.12451

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