ELF1 Antibody

說明書

中文名稱：

ELF1兔多克隆抗體
貨號：

CSB-PA007596DSR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007596DSR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007596DSR2HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ELF1 Polyclonal antibody
Uniprot No.：

P32519
基因名：

ELF1
別名：

E74 like factor 1 antibody; E74-like factor 1 antibody; ELF 1 antibody; ELF1 antibody; ELF1_HUMAN antibody; Ets domain transcription factor antibody; ETS related transcription factor Elf 1 antibody; ETS related transcription factor Elf1 antibody; ets-related transcription factor antibody; ETS-related transcription factor Elf-1 antibody; mElf 1 antibody; p70 antibody; Sts1 antibody; TRANSCRIPTION FACTOR ELF 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ETS-related transcription factor Elf-1 protein (1-210AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
基因功能參考文獻：
1. ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region. PMID: 26553150
2. ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation. PMID: 26643049
3. Data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients. PMID: 21811762
4. Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells. PMID: 21931859
5. The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density. PMID: 20346215
6. the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells. PMID: 21867680
7. through a genome-wide association in a Hong Kong Chinese cohort and replication in 2 other Asian populations, identified association of ELF1 with systemic lupus erythematosus PMID: 21044949
8. The expression levels of both Elf-1 and VEGF were significantly related with tumor differentiation, lymphatic metastasis, clinical stage, and postoperative survival time in non-small cell lung cancer. PMID: 19624906
9. ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression PMID: 20600580
10. transcriptional regulation of the LAT gene, including the discovery that the Ets transcription factor Elf-1 may play a central role in its expression PMID: 16464244
11. These results provide new evidence that Elf-1 is involved in transcriptional activation of hPygo2. PMID: 18314487
12. Elf-1 in combination with Sp1 and GABP reduced FcRgamma promoter activity. PMID: 18378679
13. aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231, resulting in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters. PMID: 18714041
14. Includes a comparison of MEF to ELF1. PMID: 10207087
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亞細胞定位：

Nucleus.
蛋白家族：

ETS family
組織特異性：

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, l
數據庫鏈接：

HGNC: 3316

OMIM: 189973

KEGG: hsa:1997

STRING: 9606.ENSP00000239882

UniGene: Hs.135646

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