ELAC2 Antibody
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中文名稱：ELAC2兔多克隆抗體
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貨號：CSB-PA997561
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA997561(ELAC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA997561(ELAC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, Hela cells, Primary antibody: CSB-PA997561(ELAC2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ELAC2
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別名：COXPD17 antibody; elaC homolog 2 (E. coli) antibody; ElaC homolog protein 2 antibody; elaC ribonuclease Z 2 antibody; elaC, E. coli, homolog of, 2 antibody; ELAC2 antibody; ELC2 antibody; FLJ10530 antibody; FLJ36693 antibody; FLJ42848 antibody; Heredity prostate cancer protein 2 antibody; HPC2 antibody; putative prostate cancer susceptibility protein HPC2/ELAC2 antibody; Ribonuclease Z 2 antibody; Ribonuclease Z, long form antibody; Ribonuclease Z2 antibody; RNase Z 2 antibody; RNase Z2 antibody; RNase ZL antibody; RNZ2_HUMAN antibody; tRNA 3 endonuclease 2 antibody; tRNase Z (long form) antibody; tRNase Z 2 antibody; tRNase Z2 antibody; Zinc phosphodiesterase ELAC protein 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human ELAC2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:200-1:1000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
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基因功能參考文獻(xiàn)：
- This study describes the cardiac phenotype and outcome of ELAC2 mutation in Infantile Cardiomyopathy PMID: 28441660
- ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2. PMID: 27318894
- A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement PMID: 27769300
- ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. PMID: 23849775
- results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P PMID: 21593607
- ELAC2 and PTCD1 affect the 3' end processing of tRNAs. PMID: 21857155
- analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation PMID: 21559454
- Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in an Indian population. PMID: 20119870
- ELAC2 polymorphisms are associated with prostate cancer. PMID: 20231859
- Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history. PMID: 20086112
- variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago PMID: 12384782
- Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer PMID: 12515253
- Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese. PMID: 12522685
- ELAC2 interacts with the gamma-tubulin complex and perturbation of ELAC2 might promote tumorigenesis through irregular cell division PMID: 12569551
- There is no evidence that either ELAC2 polymorphism is associated with prostate cancer or PSA level. PMID: 12783937
- polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men PMID: 12949798
- When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06]. PMID: 14504198
- ELAC2 has a role in prostate cancer PMID: 14625808
- Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan. PMID: 15368467
- Single nucleotide polymorphisms associated with hereditary prostate cancer. PMID: 16114055
- candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses PMID: 16636667
- The oncogenic role of HPC2 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
- Common SNPs and haplotypes of ELAC2 are associated with risk of aggressive prostate cancer. PMID: 18375959
- Changes in K(M) observed with some of the substitutions suggest contacts between tRNase Z and substrate tRNA in this region, and changes in tRNA structure provide an additional basis for interpretation of the kinetic effects.[tRNase Z] PMID: 18421255
- HPC2/ELAC2 and RNASEL may play a role, however minor, in prostate cancer risk among African American men. PMID: 18767027
- The findings reveal that 3' end processing is a limiting step for defective tRNA maturation and demonstrate that overexpression of ELAC2 can promote defective tRNA 3' processing in vivo. PMID: 19555350
- The present data suggest the possibility that human cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells. PMID: 19751732
- Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 15824169
- ELAC2 harbors mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two Utah pedigrees PMID: 11175785
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相關(guān)疾病：Prostate cancer, hereditary, 2 (HPC2); Combined oxidative phosphorylation deficiency 17 (COXPD17)
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亞細(xì)胞定位：Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Note=Mainly mitochondrial.
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蛋白家族：RNase Z family
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組織特異性：Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
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