EF hand domain containing protein 2 antibody; EF hand domain family; member D2 antibody; EF-hand domain-containing protein D2 antibody; EFHD 2 antibody; EFHD2 antibody; EFHD2_HUMAN antibody; RP3-467K16.3 antibody; Swiprosin 1 antibody; Swiprosin-1 antibody; SWS1 antibody
宿主:
Rabbit
反應種屬:
Human
免疫原:
Recombinant Human EF-hand domain-containing protein D2 protein (2-240AA)
免疫原種屬:
Homo sapiens (Human)
標記方式:
FITC
克隆類型:
Polyclonal
抗體亞型:
IgG
純化方式:
>95%, Protein G purified
濃度:
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
基因功能參考文獻:
Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2. PMID: 27974828
Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure. PMID: 28011271
The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state. PMID: 24917152
EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia. PMID: 25383639
Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity. PMID: 23977092
Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183 PMID: 23959172
EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration. PMID: 23331044
the human Shu complex (hSWS1.SWSAP1) has an evolutionarily conserved function in homologous recombination PMID: 21965664
This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes. PMID: 15274114
These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway. PMID: 19693767
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亞細胞定位:
Membrane raft.
組織特異性:
Found in lymphocytes; preferentially expressed in CD8+ cells.