EDNRB Antibody

說明書

中文名稱：

EDNRB兔多克隆抗體
貨號：

CSB-PA937611
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA937611(EDNRB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA937611(EDNRB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, human fetal lung tissue, human intestines tissue, human lung tissue, Primary antibody: CSB-PA937611(EDNRB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P24530
基因名：

EDNRB
別名：

EDNRB; ETRB; Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human EDNRB
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻：
1. the joint effect of polymorphisms of EDNRB and NOS3 on diabetic retinopathy risk was greater than the individual effect of each polymorphism in the analyzed genetic models PMID: 28817788
2. the results suggest that aberrant expression of Gli1 serves a role in HSCR by targeting EDNRB. PMID: 29484400
3. Endothelin B receptor (ETBR) is overexpressed in glioblastoma and may be a prognostic marker and useful target for treating cancer patients. PMID: 29409474
4. our current findings suggest that human neutrophils display functional ETB receptors with calcium signaling capability, leading to accentuated adhesion to the endothelium. PMID: 28385784
5. ETBR function contributes to diminished endothelium-dependent dilation in previously preeclamptic women. PMID: 29042489
6. An IL2-targeted antibody failed to detect transfected ETB in HEK293 cultures. In contrast, the NT-targeted antibody accurately detected transfected ETB in HEK293 cultures by labeling a 37-kDa band. PMID: 25232999
7. This study concluded that ETB receptors mediate vasodilation in young women, but this effect is lost after menopause. PMID: 28438762
8. Our results suggest that EDNRB rs5351 single nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin. PMID: 28350619
9. No rare EDNRB variants were identified among 57 patients with Hirschsprung disease. PMID: 26395553
10. Taking into account that the cohort we screened was deprived of patients previously found mutated in MITF (about 15%) and SOX10 (another 15%), our 8% mutation rate indicates that EDNRB heterozygous mutations represent about 5%-6% of all WS2, making it the third gene of this subtype. PMID: 28236341
11. The high level of ETBR expression observed in CMS patients compared to healthy controls suggests that the cerebral hypoxia diastolic reaction is possible due to ETBR, rather than ET-1 itself. PMID: 27485004
12. crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1 PMID: 27595334
13. Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. PMID: 27134165
14. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies PMID: 27193723
15. Serum EDNRB hypermethylation is a highly specific but not sensitive serum biomarker for HNSCC PMID: 24995714
16. High Endothelin B receptor expression is associated with malignant gliomas. PMID: 26645886
17. EDNRB plays a key role in hypoxia tolerance PMID: 26240367
18. The increased gene expression of MITF and EDNRB in UVB-exposed NHMs. PMID: 26030901
19. culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB PMID: 26308584
20. Polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels PMID: 25799405
21. Cumulative effects of the RET and EDNRB genes contribute to long-segment and total colonic aganglionosis. PMID: 25638620
22. Endothelin receptor B expression was significantly lower while higher staining grade was found in basal cell carcinoma rather than squamous cell carcinoma or psoriasis. PMID: 25946671
23. Its expression by lymphoma and endothelial cells may mediate trafficking of tumor-infiltrated lymphocytes, which may explain the immune escape processes of primary central nervous system lymphomas. PMID: 25433721
24. The results show that MitA can effectively be used to block ETBR mediated vasoconstriction as a supplement to an existing ischemic stroke therapy. PMID: 25479176
25. Identification of heterozygous deletion of the entire EDNRB in a father and 2 children. Since heterozygous deletion was the only change identified in EDNRB, the family represents one of the few cases of autosomal dominant inheritance of Waardenburg type 4 PMID: 25118007
26. The anti-EDNRB ADC combines well with BRAF and MEK inhibitors and could have therapeutic use in the majority of human melanoma cases. PMID: 24651527
27. A novel stop mutation in the EDNRB gene was found in a family with Hirschsprung's disease associated with multiple sclerosis. PMID: 24726125
28. No biologically significant correlation was observed in the ETBR immunohistochemistry of human pancreatic ductal adenocarcinoma sections PMID: 24549269
29. There was no difference in EDNRB mRNA expression between reflux esophagitis, Barrett's esophagus, and controls. PMID: 23384184
30. Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. PMID: 24326135
31. The endothelin B receptor was demonstrated to mediate the proliferation of oligodendroglioma cells according to an ERK-dependent mechanism. PMID: 24145738
32. The -615 to -624 bp region is the key binding site of AP-1 in ETB receptor promoter and was found to be crucial for inducible ETB receptor expression. PMID: 24265756
33. The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). PMID: 24039914
34. Gene expression profiling for uveal melanoma may be obtained from patients who were previously treated with radiotherapy PMID: 24511587
35. Endothelin receptor type B expression was correlated with several clinicopathological factors including tumor differentiation, tumor depth, and lymph node metastasis. PMID: 24357795
36. EDNRB is generally accepted as a major gene for Hirschsprung's disease. PMID: 23579558
37. Endothelin receptor type B is a novel pathway and therapeutic target for enhancing remyelination in multiple sclerosis. PMID: 23518706
38. Expression of endothelin A and B receptors and endothelin-1 in the pulmonary arteries is significantly increased in failed Fontan patients. PMID: 21356562
39. Data indicate that endothelin receptor B (EDNRB) overexpression facilitates intracranial melanoma growth. PMID: 22865454
40. Our findings demonstrate that aldosterone modulates an ET(B) cysteinyl thiol redox switch to decrease pulmonary endothelium-derived NO(.) and promote pulmonary arterial hypertension. PMID: 22787113
41. Loss of EDNRB is associated with metastasis in clear-cell renal cell carcinoma. PMID: 22213152
42. results obtained give evidence of a possible participation of receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis PMID: 22535604
43. promoter hypermethylation of EDNRB gene is highly prevalent in gastric cancer PMID: 21264540
44. In transgenic Ednrb-deficient mice, sacral crest-derived cells diminish in number from fetal to postnatal stages. PMID: 21858821
45. Survival analysis shows that the ETB receptor high expression group had significantly shorter disease-free survival and overall survival rates than the low expression group. PMID: 21770857
46. Attenuated ET-B receptor mediated vasodilatation during local skin warming compared to Controls. PMID: 21825025
47. 3 novel mutations in EDNRB gene associated with Waardenburg-Shah syndrome (WS4) in Pakistani patients. PMID: 21547364
48. No association of S305N EDNRB polymorphism with sporadic melanoma risk in the French or Italian populations, but there was an indication that EDNRB might be a melanoma-predisposing gene in French patients with a hereditary predisposition to melanoma. PMID: 21507037
49. Endothelin type B receptor-mediated contractions of the cerebrovasculature are significantly reduced following inhibition of B-raf kinase. PMID: 21223556
50. cigarette smoke extract induced ET(B) receptor overexpression by a feed forward mechanism mediated partly by ET release, promoting pulmonary artery endothelial cell dysfunction and attenuated by ET(B) receptor blockade, Rho kinase and ROS inhibition PMID: 20698855
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相關疾病：

Waardenburg syndrome 4A (WS4A); Hirschsprung disease 2 (HSCR2); ABCD syndrome (ABCDS)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
組織特異性：

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
數據庫鏈接：

HGNC: 3180

OMIM: 131244

KEGG: hsa:1910

STRING: 9606.ENSP00000366416

UniGene: Hs.732046

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