EDIL3 Antibody

說明書

中文名稱：

EDIL3兔多克隆抗體
貨號：

CSB-PA007399ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: EDIL3 antibody at 3.09µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Lane 4: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54, 53 kDa
Observed band size: 54 kDa

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA007399ESR1HU at dilution of 1:100
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產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) EDIL3 Polyclonal antibody
Uniprot No.：

O43854
基因名：

EDIL3
別名：

DEL1 antibody; Developmental endothelial locus 1 antibody; Developmentally regulated endothelial cell locus 1 protein antibody; Developmentally-regulated endothelial cell locus 1 protein antibody; Edil3 antibody; EDIL3_HUMAN antibody; EGF like repeat and discoidin I like domain containing protein 3 antibody; EGF like repeats and discoidin I like domains 3 antibody; EGF like repeats and discoidin I like domains protein 3 antibody; EGF-like repeat and discoidin I-like domain-containing protein 3 antibody; Integrin binding protein DEL1 antibody; Integrin-binding protein DEL1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human EGF-like repeat and discoidin I-like domain-containing protein 3 protein (60-300AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
基因功能參考文獻：
1. EDIL3 may be implicated in retinal neovascularization in vitro. Silencing EDIL3 expression was demonstrated to impair the proliferative, migratory and tube forming capabilities of HRECs in vitro. PMID: 28765888
2. these data reveal an unrecognised function of endogenous Del-1 as a local inhibitor of ischaemia-induced angiogenesis by restraining LFA-1-dependent homing of pro-angiogenic haematopoietic cells to ischaemic tissues PMID: 28447099
3. Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors. PMID: 28846069
4. Del-1 pre-treatment of blood before addition of islets diminished coagulation activation and islet damage PMID: 26676803
5. Del-1 on circulating EVs is a promising marker to improve identification of patients with early-stage breast cancer and distinguish breast cancer from benign breast tumors and noncancerous diseases. PMID: 26603257
6. Overexpressed EDIL3 promotes anchorage-independent tumor growth in human pancreatic cancer. PMID: 26735172
7. Overexpression of the Del-1 gene potentiates proliferation and invasion of lung carcinoma cells. PMID: 26545781
8. The importance of interaction between EDIL3 and integrin alphaV. PMID: 25273699
9. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment. PMID: 24416060
10. Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer. PMID: 19292890
11. Del-1 may act as a gatekeeper of adrenal gland inflammation and may regulate the integrity of the hypothalamic-pituitary-adrenal axis stress response, thereby modulating adrenal (dys)function in the course of SIRS. PMID: 23364949
12. database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 PMID: 22601780
13. Del-1 mediates phosphatidylserine- and integrin-dependent endothelial uptake of microparticles by endocytosis. PMID: 22388320
14. High expression level of EDIL3 predicts poor prognosis of hepatocellular carcinoma patients. PMID: 20857535
15. Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). PMID: 11959660
16. acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis PMID: 12074641
17. Alpha v beta 5, alpha v beta 5 and their ligands Del-1 and L1 play an important role in the process of tumor cells moving from the original place. PMID: 18090124
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 3173

OMIM: 606018

KEGG: hsa:10085

STRING: 9606.ENSP00000296591

UniGene: Hs.482730

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