E2F5 Antibody
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中文名稱：E2F5兔多克隆抗體
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貨號：CSB-PA624021LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate, Rat liver tissue, Mouse liver tissue
All lanes: E2F5 antibody at 5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 21 kDa
Observed band size: 38 kDa -
IHC image of CSB-PA624021LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) E2F5 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：E2F 5 antibody; E2F transcription factor 5 antibody; E2F transcription factor 5 p130 binding antibody; E2F-5 antibody; E2f5 antibody; E2F5_HUMAN antibody; p130 binding antibody; Transcription factor E2F5 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human Transcription factor E2F5 protein (193-298AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，E2F5 Antibody (CSB-PA624021LA01HU)，的標記方式是Non-conjugated。對于E2F5 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
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基因功能參考文獻：
- High E2F5 expression is associated with Glioma. PMID: 29362021
- knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression. Conversely, concomitant knockdown of miR-1-3p and E2F5 and PFTK1 substantially reversed the inhibitory effects of either E2F5 or PFTK1 silencing alone. PMID: 30185212
- miR-1179 overexpression could also inhibit tumor growth in vivo by suppressing the expression of E2F5. PMID: 29859832
- FOXN3 functions as a tumor suppressor in hepatocellular carcinoma by downregulating the expression of E2F5. PMID: 27259277
- Taken together, these findings indicated that SNHG16 induces breast cancer cell migration by competitively binding miR-98 with E2F5. PMID: 28232182
- Our data collectively indicate that miR-613 functions as a tumor suppressor in retinoblastoma through downregulating E2F5, supporting the targeting of the novel miR-613/E2F5 axis as a potentially effective therapeutic approach for retinoblastoma. PMID: 28351331
- MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
- miR-98 regulates muscle differentiation by altering the expression of the transcription factor E2F5 and, in turn, of multiple E2F5 targets. PMID: 25422988
- In hepatocellular carcinoma cells hepatitis B virus down-regulates E2F5 expression by up-regulating expression of miR-181a. PMID: 24529171
- expression of E2F5 in esphageal squamous cell cancer (ESCC) may be correlated with a worse prognosis of patients with ESCC PMID: 24324077
- E2F5 may be a novel potential candidate marker for malignant prostate cancer PMID: 23377984
- Data indicate that E2F5 is commonly overexpressed in primary hepatocellular carcinomas and show that E2F5 knockdown significantly repressed the growth of HCC cells. PMID: 21274376
- cell-cycle regulatory protein E2F5 might play a significant role in epithelial ovarian cancer pathogenesis PMID: 20181230
- Diverting the function of E2F5 from a cell-cycle repressor into an activator might contribute to the higher oncogenic potential of HPV18 when compared with other high-risk HPV types. PMID: 20639900
- the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. PMID: 12089160
- EBV LPM1 blocks p16INK4 pathway by promoting nuclear export of E2F-5. PMID: 12860972
- E2F5 protein is down-regulated late in embryogenesis PMID: 16172982
- Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process. PMID: 18385796
- Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. PMID: 19259095
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亞細胞定位：Nucleus.
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蛋白家族：E2F/DP family
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數據庫鏈接：
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