DVL3 Antibody
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中文名稱：DVL3兔多克隆抗體
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貨號(hào)：CSB-PA007287GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Dishevelled 3 (homologous to Drosophila dsh) antibody; Dishevelled 3 antibody; Dishevelled 3; dsh homolog (Drosophila) antibody; Dishevelled; dsh homolog 3 (Drosophila) antibody; Dishevelled-3 antibody; DSH homolog 3 antibody; dvl3 antibody; DVL3_HUMAN antibody; KIAA0208 antibody; OTTHUMP00000210777 antibody; OTTHUMP00000210778 antibody; Segment polarity protein dishevelled homolog DVL 3 antibody; Segment polarity protein dishevelled homolog DVL-3 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human DVL3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IF
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Involved in the signal transduction pathway mediated by multiple Wnt genes.
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基因功能參考文獻(xiàn)：
- Dvl3 is overexpressed in human HCCs. The NP-Dvl3 is the more stable and active form of the protein and enhances HCC stemness. PMID: 28455968
- Studied and identified candidate biomarkers of biochemical recurrence (BCR) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR. DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma. PMID: 28107606
- Genetic changes between MLH1 and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034). PMID: 28705114
- Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells. PMID: 26792835
- DVL3 transcripts decreased in individuals with major depressive disorder PMID: 26008736
- we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
- All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome. PMID: 26924530
- data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway. PMID: 25847080
- Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors. PMID: 25168481
- data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5. PMID: 24993822
- AMPK activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK/mTOR signaling and/or partially promoting the proteasomal degradation of DVL3 PMID: 23301094
- A harmful p.Ser175Gly substitution & 3 benign variants (p.Ile353Val, p.Ile384Val, & p.Ala641Thr) were found in a cohort of patients with neural tube defects but not in controls. PMID: 22892949
- Dvl3 protein transduce signals via the Wnt proteins non canonical pathways, namely via NFAT protein and Src kinase and novel NPM-ALK interacting proteins and possibly NPM-ALK substrates. PMID: 23022960
- Letter: report expression of dishevelled-3 and EAAT1 and glutamine metabolism in malignant pleural mesothelioma. PMID: 22569537
- Identification of novel post translational modifications of DVL3 by liquid chromatography coupled LTQ-Orbitrap analysis. PMID: 22612246
- In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation. PMID: 21667018
- The facilitation of Prickle-1 on Dvl3 degradation and the suppression of beta-catenin activity and cell growth suggest that Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway PMID: 17030191
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相關(guān)疾病：Robinow syndrome, autosomal dominant 3 (DRS3)
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：DSH family
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數(shù)據(jù)庫(kù)鏈接：
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