DUSP10 Antibody
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中文名稱：DUSP10兔多克隆抗體
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貨號：CSB-PA006797
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規格：￥1090
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圖片：
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Western Blot analysis of 3T3 cells using DUSP10 Polyclonal Antibody -
Immunohistochemical analysis of paraffin-embedded human meningioma. DUSP10 Antibody was diluted at 1:200.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Dual specificity phosphatase 10 antibody; Dual specificity phosphatase MKP 5 antibody; Dual specificity phosphatase MKP5 antibody; Dual specificity protein phosphatase 10 antibody; DUS10_HUMAN antibody; DUSP 10 antibody; DUSP10 antibody; DUSP10 protein antibody; MAP kinase phosphatase 5 antibody; Mitogen activated protein kinase phosphatase 5 antibody; Mitogen-activated protein kinase phosphatase 5 antibody; MKP 5 antibody; MKP-5 antibody; MKP5 antibody; Serine/threonine specific protein phosphatase antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Synthesized peptide derived from the C-terminal region of Human MKP-5.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:25-1:200 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
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基因功能參考文獻：
- Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants PMID: 29986742
- High DUSP10 expression is associated with Metastasis of Hepatocellular Carcinoma. PMID: 28674078
- Increased Dusp10 expression is associated with better survival rate in colorectal cancer patients. PMID: 25772234
- In females, three SNPs were associated with decreased colorectal cancer risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased colorectal cancer risk. PMID: 25973098
- Data suggest that vitamin D receptor target genes (DUSP10; THBD, thrombomodulin; NRIP1, nuclear receptor interacting protein 1; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
- Certain mutations in DUSP10 correlate with the incidence of colorectal cancer(CRC). Thus, the function of the DUSP10 gene product may contribute toward CRC in the Han Chinese population. PMID: 23872954
- Single nucleotide polymorphism in DUSP10 gene is associated with celiac disease. PMID: 23936387
- Depletion of miR-181 family members by miRNA inhibitors enhanced the expression of MKP-5 and suppressed the phosphorylation of p38 MAPK after exposure to PAHs, which promotes cancer cell migration. PMID: 23993976
- Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
- MKP-5 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription. PMID: 22711061
- A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5. PMID: 22375048
- DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
- a function for ASC that is distinct from the inflammasome in modulating MAPK activity and chemokine expression and further identify DUSP10 as a novel ASC target. PMID: 21487011
- Structural information provides an explanation of constitutive activity of MKP5 as well as the structural insight into substrate-induced activation occurred in other MKPs. PMID: 16806267
- Mitogen-activated protein kinase phosphatase-5 (MKP5) mediates anti-inflammatory activities of phytochemicals curcumin, resveratrol and [6]-gingerol. PMID: 17151092
- Catalytic domain of MKP5 is in an active conformation, and two loops in the active site have backbone shifts of up to 5 A. PMID: 17400920
- The transcription factor ATF2, which is phosphorylated and activated by JNK, is a critical mediator for inducible expression of DUSP1 and DUSP10 in this signaling pathway. PMID: 17681939
- p38 MAP kinase down-regulates extracellular signal-regulated kinase via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression. PMID: 18314537
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
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組織特異性：Expressed in keratinocytes (at protein level). Detected in brain.
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數據庫鏈接：
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