DSG1 Antibody
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中文名稱：DSG1兔多克隆抗體
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貨號：CSB-PA620185
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規格：￥1090
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圖片：
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Western blot analysis of Mouse kidney tissue, Mouse brain tissue, Mouse lung tissue, Mouse heart tissue, 293T whole cell lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000 -
Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
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其他：
產品詳情
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Uniprot No.：
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基因名：DSG1
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別名：DSG1; CDHF4; Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide from Human protein at AA range: 30-90
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-2000 IHC 1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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基因功能參考文獻：
- Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. PMID: 28891468
- Compared with immunocompetent patients, kidney transplant recipients systemically treated with calcineurin inhibitors and mycophenolate mofetil exhibited significantly reduced epidermal expression of Dsg1, a regulator of keratinocyte differentiation and barrier function. PMID: 27302902
- Study identified DSG1 to be involved in the progressive intestinal injury associated with the development of Crohn's Disease complications via its effect on intestinal cell adhesion. PMID: 28490445
- The authors report one recurrent and five novel DSG1 mutations, causing varying patterns of PPK, highlighting the clinical heterogeneity arising from mutations in this gene. PMID: 27534273
- Authors report a new family of severe dermatitis, multiple allergies and metabolic wasting syndrome of Asian decent and expand the spectrum of mutations in the DSG1 gene. PMID: 27154412
- Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 and SERPINB7. PMID: 27786350
- Genetic deletion of sdrD in S. aureus NCTC8325-4 through allelic replacement resulted in decreased bacterial adherence to Dsg1- expressing HaCaT cells in vitro. PMID: 26924733
- The results of this study describes the fourth family with a biallelic mutation in the DSG1 gene associated with SAM syndrome, and emphasizes that the presence of PPK and skin fragility with or without additional symptoms should alert clinicians to consider DSG1 deficiency. PMID: 26288349
- Desmoglein 1 mutation as cause of SAM syndrome PMID: 26169895
- Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. PMID: 24220297
- Ectopic expression of Dsg1 in keratinocyte monolayers rescued the UVB-induced differentiation defect PMID: 24594668
- The data showed that serum autoantibodies of patients, previously identified as Dsg1 and Dsg3 positive, are able to recognize continuous linear epitope regions of both Dsg1 and Dsg3 proteins using pin-bound overlapping peptides in modified ELISAs. PMID: 23297065
- The loss of Bcr or MAL reduced levels of Dsg1 mRNA in keratinocytes, and ectopic expression of Dsg1 rescued defects in differentiation seen upon loss of Bcr or MAL signaling. PMID: 23940119
- DSG1 deficiency was associated with increased expression of a number of genes encoding allergy-related cytokines PMID: 23974871
- IgG autoantibodies against Dsg1 are mostly raised against preDsg1 and/or C-terminal domains of Dsg1 in healthy Tunisians in the endemic area of pemphigus foliaceus. PMID: 23489520
- DSG1 and Erbin cooperate to repress MAPK signaling and promote keratinocyte differentiation. PMID: 23524970
- we show that the LJM11 salivary protein from the sand fly are recognized by pemphigus foliaceus autoantibodies against desmoglein 1 PMID: 22798673
- Induced gene expression levels of plakoglobin, desmoglein-1 and desmoglein-2 correlated significantly with dilatation of intercellular spaces and basal cell hyperplasia in esophageal mucosa of patients with gastro-oesophageal reflux disease. PMID: 22276604
- The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. PMID: 22189787
- anti-DSG1 response in fogo selvagem patients may be initiated by sensitization to an environmental allergen PMID: 21191415
- KLK5 may promote metastatic dissemination of OSCC by promoting loss of junctional integrity through cleavage of desmoglein 1. PMID: 21163944
- Data show that desmoglein 1 expression was required for the adhesive effects of EphA2. PMID: 20861311
- Histone deacetylase inhibition up-regulates desmosomal cadherins and prevents the loss of adhesion induced by Dsg1 truncation. PMID: 21075858
- localized on corneodesmosomes involved in adhesion PMID: 20116975
- data demonstrate the role of epistasis between individual genes in Pemphigus foliaceus susceptibility and illustrate the genetic complexity of organ-specific autoimmune diseases; Epistasis between DSG1 and HLA class II genes PMID: 12058255
- Staphylococcal exfoliative toxins act as serine proteases with extremely focused molecular specificity to cleave mouse and human desmoglein 1 (Dsg1) once after glutamic acid residue 381 between extracellular domains 3 and 4. PMID: 12093888
- During high-level expression, keratin insertion at cell-cell contact sites was inhibited in desmoglein 1 but not in desmoglein 3, and desmoplakin was stained at cell-cell contact sites in desmoglein 3 but not in desmoglein 1. PMID: 12485422
- Desmoglein 1 defined more differentiated cell populations, and was expressed in epidermal suprabasal cells, the inner root sheath, and the innermost layers of the outer root sheath. PMID: 12787134
- Signaling pathway initiated by structural changes in the adherens junction in which adherens-junction-derived plakoglobin regulates nuclear transcription by antagonizing the binding of beta-catenin to T cell factor/lymphoid enhancer factor proteins. PMID: 12880414
- Specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid sequences but also in its calcium-dependent conformation. PMID: 12880431
- a detailed epitope mapping reveals that the conformational epitopes recognized by IgG1 autoantibodies from these PF patients are restricted to the first 161 amino acids of Dsg1, whereas the linear epitopes are spread throughout the entire ectodomain. PMID: 14675185
- Dsg1 promotes the formation of intercellular adhesion complexes. PMID: 15606501
- a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5 domain of desmoglein 1 PMID: 15610512
- T-cell autoreactivity against Dsg1 is seen both in patients with pemphigus foliaceus and in healthy individuals PMID: 16026580
- No significant relationship is revealed between genetic variants of autoantigen desmoglein 1 and pemphigus foliaceus in the Brazilian population. PMID: 16242304
- desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes PMID: 16286477
- perturbation of desmoglein 1 expression has a critical impact on the integrity of tissues experiencing strong mechanical stress. PMID: 16484817
- An alternative transcript of DSG1, which contains a 101-bp insertion corresponding to the 3' end of DSG1-intron 6 and introducing a stop codon in the nucleotide sequence, is described. PMID: 17056584
- Taken together, our results represent the first demonstration that anti-Dsg1 antibodies induce similar alterations on the subcellular distribution of Dsg1 irrespective of the disease where they come from. PMID: 17058228
- novel splice site mutation in the DSG1 gene in palmoplantar keratoderma PMID: 17194569
- Data show that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were effective in causing epidermal splitting in human skin and keratinocyte dissociation. PMID: 17640963
- IgM anti-Dsg1 are common in fogo selvagem patients in their native environment and uncommon in other pemphigus phenotypes PMID: 17960181
- findings show that mRNA of the DSG1 gene is present in normal thymus and that the expression of DSG1 transcript increases with age PMID: 18331528
- The level of Dsg1, a marker of differentiating keratinocytes, was antagonistically regulated by two Ca-independent 'novel' nPKC isoforms; i.e. it increased by the differentiation-promoting nPKCdelta and decreased by the growth-promoting nPKCepsilon. PMID: 18637128
- Decreased expression of desmoglein 1 is associated with a worse prognosis in head and neck squamous cell carcinoma patients PMID: 18752129
- Direct sequencing of cDNA derived from affected skin in one patient failed to reveal a pathogenic mutation, suggesting that SPPK results from haploinsufficiency for DSG1. PMID: 19018793
- The desmoglein-specific cytoplasmic region is an intrinsically disordered functional domain with an inducible structure that, along with the membrane proximal region, forms a flexible scaffold for cytoplasmic assembly at the desmosome. PMID: 19136012
- Mutations in the desmoglein 1 gene have been indentified in five Pakistani families with striate palmoplantar keratoderma. PMID: 19157795
- Pemphigus foliaceus is an autoimmune blistering skin disease characterized by the production of pathogenic IgG autoantibodies directed against desmoglein 1. PMID: 19453789
- Data show that Dsg1 is required for maintaining epidermal tissue integrity in superficial layers, supports keratinocyte differentiation and suprabasal morphogenesis, and is required for suppression of epidermal growth factor receptor signaling. PMID: 19546243
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相關疾病：Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1); Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
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組織特異性：Epidermis, tongue, tonsil and esophagus.
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數據庫鏈接：
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