DPY19L2 Antibody

中文名稱：

DPY19L2兔多克隆抗體
貨號(hào)：

CSB-PA757514LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA757514LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DPY19L2 Polyclonal antibody
Uniprot No.：

Q6NUT2
基因名：

DPY19L2
別名：

DPY19L2 antibody; UNQ3127/PRO10284 antibody; Probable C-mannosyltransferase DPY19L2 antibody; EC 2.4.1.- antibody; Dpy-19-like protein 2 antibody; Protein dpy-19 homolog 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，DPY19L2 Antibody (CSB-PA757514LA01HU)，的標(biāo)記方式是Non-conjugated。對于DPY19L2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA757514LB01HU	DPY19L2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA757514LC01HU	DPY19L2 Antibody, FITC conjugated
Biotin	CSB-PA757514LD01HU	DPY19L2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
基因功能參考文獻(xiàn)：
1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957
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相關(guān)疾病：

Spermatogenic failure 9 (SPGF9)
亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Dpy-19 family
組織特異性：

Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 19414

OMIM: 613893

KEGG: hsa:283417

STRING: 9606.ENSP00000315988

UniGene: Hs.533644

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