DPPA3 Antibody, FITC conjugated

說明書

中文名稱：

DPPA3兔多克隆抗體, FITC偶聯
貨號：

CSB-PA744290LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DPPA3 Polyclonal antibody
Uniprot No.：

Q6W0C5
基因名：

DPPA3
別名：

Compaction associated protein 1 antibody; Developmental pluripotency associated 3 antibody; Developmental pluripotency associated protein 3 antibody; Developmental pluripotency-associated protein 3 antibody; Dppa3 antibody; DPPA3_HUMAN antibody; PGC7 antibody; Stella related protein antibody; Stella-related protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Developmental pluripotency-associated protein 3 protein (1-159AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.
基因功能參考文獻：
1. Super-enhancers at the Nanog locus differentially regulate neighboring pluripotency-associated genes, in particular, DPPA3. PMID: 27681417
2. We conclude that heterogeneous population of the HEK293T cells might be easily shifted towards expression of the pluripotency markers by ectopic expression of the SON factors or by growth in serum depleted media. PMID: 27794480
3. Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression. PMID: 26608031
4. Considering that impaired DNA methylation profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation PMID: 25280994
5. a role for STELLA in facilitating germline and endodermal differentiation of human ES cells PMID: 23457636
6. human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3 PMID: 16291741
7. These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization. PMID: 17143267
8. In mice, this gene may play a role in oogenesis and primordial germ cell development. PMID: 11900980
9. In mice, a targeted mutation results in reduced female fertility and may function as a mammalian maternal effect gene. PMID: 14654002
10. In mice, knockout experiments show this gene may be a maternal factor in cleavage stage embryogenesis. PMID: 15018652
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亞細胞定位：

Nucleus. Cytoplasm.
組織特異性：

Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors.
數據庫鏈接：

HGNC: 19199

OMIM: 608408

KEGG: hsa:359787

STRING: 9606.ENSP00000339250

UniGene: Hs.131358

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