DPP9 Antibody, HRP conjugated

說明書

中文名稱：

DPP9兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA769770LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DPP9 Polyclonal antibody
Uniprot No.：

Q86TI2
基因名：

DPP9
別名：

Dipeptidyl peptidase 9 antibody; Dipeptidyl peptidase IV related protein 2 antibody; Dipeptidyl peptidase IV-related protein 2 antibody; Dipeptidyl peptidase IX antibody; Dipeptidyl peptidase like protein 9 antibody; Dipeptidyl peptidase-like protein 9 antibody; Dipeptidylpeptidase 9 antibody; Dipeptidylpeptidase IX antibody; DKFZp762F117 antibody; DP 9 antibody; DP9 antibody; DPLP 9 antibody; DPLP9 antibody; DPP 9 antibody; DPP IX antibody; DPP9 antibody; DPP9_HUMAN antibody; DPRP 2 antibody; DPRP-2 antibody; DPRP2 antibody; FLJ16073 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Dipeptidyl peptidase 9 protein (289-437AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
基因功能參考文獻：
1. The data of this study have shown that fibroblasts and keratinocytes of normal skin endogenously express DPP9 both at transcriptional and protein level. It is localized intracellularly, mostly in cytoplasm, whereby the sub-localization within Golgi is very scarce. PMID: 27682012
2. DPP9 has a role in promoting tumorgenicity, metastasis and the prediction of poor prognosis in non-small cell lung cancer PMID: 27943262
3. The DPP9 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP9. PMID: 25464020
4. There was a concomitant decrease in the phosphorylation of focal adhesion kinase and paxillin, indicating that DPP9 knockdown or enzyme inhibition suppressed the associated adhesion signaling pathway, causing impaired cell movement. PMID: 25486458
5. Whereas DPP9-short is present in the cytosol, DPP9-long localizes preferentially to the nucleus. PMID: 24562348
6. DPP9 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
7. DPP9 binds to SUMO1 through a novel SUMO1 interacting motif. PMID: 23152501
8. residues important for dimer formation and enzymatic activity PMID: 22001206
9. These findings suggest an important signaling role of DPP9 in the regulation of survival and proliferation pathways. PMID: 21622624
10. This is the first study to demonstrate the presence of DP9 in chronic lymphocytic leukemia. PMID: 20534982
11. identification of two forms, their tissue distribution, cytoplasmic localization PMID: 15245913
12. cells overexpressing DP9 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
13. The DPP9 gene is not associated with the occurrence or curve severity of AIS. It is neither a disease-predisposition nor a disease-modifying gene of AIS. PMID: 18940951
14. results indicate that the biochemical property of DPP9 is very similar to that of DPP8, its homologous protease. DPP9 and DPP8 are likely redundant proteins carrying out overlapping functions in vivo PMID: 19268648
15. DPP9, a poorly characterized cytoplasmic prolyl-peptidase, is rate-limiting for destruction of proline-containing substrates both in cell extracts and in intact cells PMID: 19667070
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亞細胞定位：

[Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Nucleus.
蛋白家族：

Peptidase S9B family, DPPIV subfamily
組織特異性：

Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
數(shù)據(jù)庫鏈接：

HGNC: 18648

OMIM: 608258

KEGG: hsa:91039

STRING: 9606.ENSP00000262960

UniGene: Hs.515081

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