DND1 Antibody, FITC conjugated
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中文名稱：DND1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA809023LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DND1 Polyclonal antibody
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Uniprot No.：
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基因名：DND1
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別名：Dead end homolog 1 (zebrafish) antibody; dead end homolog 1 antibody; Dead end protein antibody; Dead end protein homolog 1 antibody; Dead end; zebrafish; homolog; 1 antibody; DND microRNA-mediated repression inhibitor 1 antibody; dnd1 antibody; DND1_HUMAN antibody; MGC34750 antibody; RBMS4 antibody; RNA binding motif single stranded interacting protein 4 antibody; RNA-binding motif antibody; single-stranded-interacting protein 4 antibody; Ter antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dead end protein homolog 1 protein (37-180AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.
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基因功能參考文獻：
- Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479
- Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469
- RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
- APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083
- The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019
- Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623
- We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342
- Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328
- Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
- MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342
- The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663
- Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663
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亞細胞定位：Nucleus. Cytoplasm.
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