DNAJC3 Antibody

中文名稱：

DNAJC3兔多克隆抗體
貨號：

CSB-PA615670LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA615670LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA615670LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA615670LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DNAJC3 Polyclonal antibody
Uniprot No.：

Q13217
基因名：

DNAJC3
別名：

DnaJ (Hsp40) homolog subfamily C member 3 antibody; DnaJ homolog subfamily C member 3 antibody; DNAJC3 antibody; DNJC3_HUMAN antibody; double-stranded RNA-activated protein kinase inhibitor antibody; Endoplasmic reticulum DnaJ protein 6 antibody; ERdj6 antibody; HP58 antibody; Interferon induced; double stranded RNA activated protein kinase inhibitor antibody; Interferon-induced antibody; P58 antibody; p58 ipk antibody; P58IPK antibody; PRKRI antibody; Protein kinase inhibitor of 58 kDa antibody; Protein kinase inhibitor p58 antibody; Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DNAJC3 Antibody (CSB-PA615670LA01HU)，的標記方式是Non-conjugated。對于DNAJC3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA615670LB01HU	DNAJC3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA615670LC01HU	DNAJC3 Antibody, FITC conjugated
Biotin	CSB-PA615670LD01HU	DNAJC3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
基因功能參考文獻：
1. DNAJC3 p.H238N is likely to be a variant causing diabetes. PMID: 29767246
2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis PMID: 25329545
3. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans. PMID: 25466870
4. p58(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K/Akt pathway that requires activation of ATF6a and subsequently upregulates mitofusin 2. PMID: 24134518
5. interplay between p38 phosphorylation and p58(IPK) upregulation has key roles in modulating ERp29-induced cell-growth arrest and survival PMID: 22064321
6. the crystal structure of human P58(IPK) PMID: 21799829
7. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. PMID: 20554776
8. Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division. PMID: 12034040
9. P58(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha signaling, and thus attenuate the unfolded protein response. PMID: 12601012
10. The study demonstrates that P58(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells. PMID: 18568130
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相關疾病：

Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD)
亞細胞定位：

Endoplasmic reticulum.
組織特異性：

Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
數據庫鏈接：

HGNC: 9439

OMIM: 601184

KEGG: hsa:5611

STRING: 9606.ENSP00000365991

UniGene: Hs.59214

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