DNAJB4 Antibody

說明書

中文名稱：

DNAJB4兔多克隆抗體
貨號：

CSB-PA727123
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA727123(DNAJB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA727123(DNAJB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human fetal liver tissue, mouse skeletal muscle tissue, Mouse heart tissue, Hela cells, Jurkat cells, Primary antibody: CSB-PA727123(DNAJB4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9UDY4
基因名：

DNAJB4
別名：

DjB4 antibody; DnaJ (Hsp40) homolog subfamily B member 4 antibody; DnaJ homolog subfamily B member 4 antibody; DnaJ like heat shock protein 40 antibody; DNAJB 4 antibody; DNAJB4 antibody; DNAJW antibody; DNJB4_HUMAN antibody; Heat shock 40 kDa protein 1 homolog antibody; Heat shock protein 40 homolog antibody; HLJ 1 antibody; HLJ1 antibody; HSP40 homolog antibody; Human liver DnaJ-like protein antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Fusion protein of Human DNAJB4
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
基因功能參考文獻：
1. These new observations support the idea that HLJ1 is a tumor suppressor candidate and potential biomarker for breast cancer PMID: 28481734
2. HLJ1 is an endogenous Src inhibitor that can suppress cancer metastasis through complex interacting mechanisms. PMID: 27065329
3. HLJ1 is a strong tumor suppressor for colorectal carcinoma PMID: 24696714
4. Low expression of DNAJB4 is associated with gastric carcinomas. PMID: 24293545
5. Silencing of HLJ1 partially reverses the inhibition of cancer-cell invasion by andrographolide. PMID: 23306212
6. HBV could promote HLJ1 expression by up-regulating the transcription factor YY1. PMID: 21345358
7. acidic stress increases the association between HLJ1 and beta-actin to modulate migration of human lung cancer cells PMID: 20615403
8. HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP-2 promoter. PMID: 20145123
9. Results indicate that DjA1 and DjB4 of subfamilies A and B of human Hsp40 have different quaternary structures and chaperone functions. PMID: 15661747
10. The increase in HLJ1 and E-cadherin expression, as well as the suppression of invasion ability, can be reversed specifically by HLJ1 siRNA. PMID: 15782117
11. HLJ1 is a novel tumor suppressor in NSCLC, and high HLJ1 expression is associated with reduced cancer recurrence and prolonged survival of NSCLC patients. PMID: 16788156
12. Results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression. PMID: 18794131
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亞細胞定位：

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
組織特異性：

Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
數(shù)據(jù)庫鏈接：

HGNC: 14886

OMIM: 611327

KEGG: hsa:11080

STRING: 9606.ENSP00000359799

UniGene: Hs.13852

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