DNAJB11 Antibody

說明書

中文名稱：

DNAJB11兔多克隆抗體
貨號：

CSB-PA033940
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from HeLa cells, HUVEC cells, COLO cells and MCF-7 cells, using DNAJB11 antibody.

Immunohistochemistry analysis of paraffin-embedded human heart tissue using DNAJB11 antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DNAJB11 Polyclonal antibody
Uniprot No.：

Q9UBS4
基因名：

DNAJB11
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human DNAJB11.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
基因功能參考文獻：
1. DNAJB11-associated disease is a phenotypic hybrid of Autosomal-dominant polycystic kidney disease and autosomal-dominant tubulointerstitial diseases. PMID: 29706351
2. ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT PMID: 28419579
3. These results reveal ERdj3 tetramerization as an important structural framework for ERdj3 functions involved in coordinating endplasmic reticulum and extracellular proteostasis in the presence and absence of endplasmic reticulum stress. PMID: 28655754
4. BiP facilitates Sec61 channel closure (i.e. limits ER Ca(2+) leakage) via the Sec61 channel with the help of ERj3 and ERj6 PMID: 26085089
5. Depleting ERdj3 reduced the rate of mutant GCase degradation in patient-derived fibroblasts, while increasing folding, trafficking, and function by directing GCase to the profolding ER calnexin pathway. PMID: 25126989
6. regulated co-secretion of ERdj3 with misfolded clients directly links ER and extracellular proteostasis during conditions of ER stress. PMID: 25361606
7. ERdj3 mutant bound to unfolded endoplasmic reticulum proteins under steady state conditions in much greater amounts than wild-type. PMID: 25143379
8. ERdjs appear to play the dual roles of increasing BiP affinity for clients and regulating delivery of clients to BiP. PMID: 23378021
9. These data identify ERdj3 as a host protein involved with the cholera toxin intoxication process and provide new molecular details regarding cholera toxin A1-chaperone interactions. PMID: 21844235
10. In addition, BiP formed a complex with SV40 capsids in the endoplasmic reticulum in a DNAJB11-dependent fashion. PMID: 21673190
11. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
12. Hsp90 and Hsp40/Erdj3 were essential for K1's anti-apoptotic function. PMID: 20418907
13. The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. PMID: 20335166
14. This protein was identified as true homolog of yeast Scj1p. PMID: 15195998
15. ERdj3 is a stress-inducible endoplasmic reticulum DnaJ homologue which serves as a cofactor for BiP's interactions with unfolded substrates PMID: 15525676
16. These data suggest that ERdj3 might have diverse roles in the ER, including that of the molecular cochaperone of BiP and an as yet unknown protective action against vero toxin.(ERDJ3) PMID: 15544163
17. These findings suggest that the Cys-rich region of HEDJ and its oxidation state are important in maintaining the substrate interaction domain in a binding-competent conformation. PMID: 17976514
18. Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions PMID: 19748898
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亞細胞定位：

Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 14889

OMIM: 611341

KEGG: hsa:51726

STRING: 9606.ENSP00000265028

UniGene: Hs.317192

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