DLX5 Antibody
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中文名稱：DLX5兔多克隆抗體
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貨號：CSB-PA006956GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：DLX5Homeobox protein DLX-5 antibody
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反應種屬：Human,Mouse,Rat
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免疫原：Human DLX5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
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基因功能參考文獻：
- Our results in mice suggest that long-range DLX5 enhancer elements located in the human SLC25A13 gene may underlie the sensorineural hearing loss that is sometimes associated with SHFM1. PMID: 29301908
- These results indicate activation of DLX5 and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis. PMID: 27645561
- these findings indicate that, in MSCs, DLX5 is a master regulator of osteogenesis. Furthermore, tanshinone IIA may be valuable for stem cell-based therapies of certain bone diseases. PMID: 28949384
- As a result of disturbed imprinting, the upregulated DLX5 affects trophoblast proliferation in preeclampsia. PMID: 28904069
- These data indicate that certain missense mutations diminish the ability of the Dlx5 homeodomain to recognize and bind target DNAs, and they likely destabilize the formation of functional complexes. PMID: 26829219
- In cells grown on titanium support, DLX5 and RUNX1 were respectively upregulated (+3.12-fold) and downregulated (-2.14-fold) PMID: 25025858
- Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I. PMID: 25332435
- Heterozygous DLX5 nonsense mutation c.G115T(p.E39X) associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated Polish families. PMID: 25196357
- A novel heterozygous mutation in exon 3 of DLX5 found in the family members with SHFM1 phenotype. PMID: 24496061
- Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted. PMID: 24459211
- The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1. PMID: 23169702
- The strongest evidence for altered methylation patterns in shiftworkers was observed for DLX5 gene. PMID: 23193016
- Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression. PMID: 22332551
- Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation. PMID: 22342398
- the first intragenic DLX5 mutation in split hand and foot malformation is found; a potential dual role for DLX5 in limb development is suggested PMID: 22121204
- DLX5 is significantly increased in heart tissue from calcific aortic valve patients compared to controls. PMID: 21205918
- MDA-MB-231 breast neoplasms did not express DLX5 but the resulting bone/lung metastases did. PMID: 21108812
- Data suggest that DLX5 plays a significant role in the pathogenesis of some ovarian cancers by enhancing IRS-2-AKT signaling. PMID: 21045156
- p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
- Results describe the expression of DLX5 and DLX6 in autistic spectrum disorder patients in an attempt to identify potential abnormality of expression. PMID: 19195802
- A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. PMID: 11959851
- DLX5 was confirmed to be imprinted in normal human lymphoblasts and brain tissues by a polymorphic analysis PMID: 12782124
- DLX5 is a target for MeCP2, linking genomic imprinting and Rett syndrome [review] PMID: 15954098
- In dental follicle cells, gene expression of runx2, DLX-5, and MSX-2 was unaffected during osteogenic differentiation in vitro. PMID: 16467978
- high expression of mutated MECP2 in TRD mutation showed bialleic expression of DLX5 suggesting loss of imprinting PMID: 17363207
- DLX5 and DLX6 are not imprinted in humans and are not likely to be direct targets of MeCP2 modulation. PMID: 17701895
- Dlx5 can act as an oncogene by cooperating with Akt2 to promote lymphomagenesis PMID: 18316591
- Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. PMID: 18413826
- The MYC promoter is specifically activated by overexpression of DLX5. PMID: 19497851
- Dlxin-1 binds Dlx5 and several additional homeodomain proteins and may regulate the function of Dlx family members in bone formation PMID: 11084035
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相關疾病：Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive (SHFM1D)
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亞細胞定位：Nucleus.
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蛋白家族：Distal-less homeobox family
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數據庫鏈接：
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