DLX4 Antibody
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中文名稱：DLX4兔多克隆抗體
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貨號：CSB-PA573952
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規格：￥2024
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圖片：
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Western blot analysis of extracts from COLO cells, using DLX4 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DLX4 Polyclonal antibody
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Uniprot No.：
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基因名：DLX4
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from C-terminal of Human DLX4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
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基因功能參考文獻：
- Beta protein 1 (BP1) binds to and regulates estrogen receptor. PMID: 27449292
- study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients PMID: 26485746
- Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. PMID: 26325005
- Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. PMID: 26208636
- DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer PMID: 26067154
- This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts PMID: 25954033
- DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. PMID: 25924901
- Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. PMID: 25614457
- indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis PMID: 26524685
- a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR-122-induced inhibition of proliferation in the HCC cell line Hep3B. PMID: 25823567
- DLX4 can functionally replace c-MYC. PMID: 25471527
- Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer. PMID: 25825198
- DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis PMID: 24947980
- The results suggest that high expression of DLX4 predicts hepatocellular carcinoma prognosis. PMID: 24824934
- All trans retinoic acid can inhibit the proliferation and the expression of BP1 in breast cancer cells. PMID: 23158431
- DLX4 induces cancer cells to undergo epithelial to mesenchymal transition through TWIST, enhancing tumor migration, invasion and metastasis. PMID: 23091415
- findings suggest that decreased expression of homeobox protein DLX-4 leads to the pathogenesis of preeclampsia by inhibiting epithelial-mesenchymal transition in trophoblasts PMID: 21602546
- The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta. PMID: 21297662
- BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. PMID: 11909945
- involvement of BP1 in the mechanism of the negative regulation of beta-globin transcription. PMID: 15308321
- BP1 can negatively modulate adult beta-globin gene expression and definitive erythroid cell differentiation, and suggest that BP1 could play a role in thalassemia. PMID: 17003054
- Increased expression of homeobox gene DLX4 may be a contributing factor to the developmental abnormalities seen in the FGR-affected placentae. PMID: 17062780
- we were able to show that enforced expression of the DLX4 homeobox gene markedly inhibited in vitro motility and invasion as well as in vivo metastasis via both hematogenous and lymphogenous routes. PMID: 17260014
- results support the notion that BP1 might contribute to breast neoplastic transformation or tumor progression and suggest for the first time that BP1 mRNA level has potential as a prognostic predictor for breast cancer PMID: 17999690
- BP1 may regulate bcl-2 and c-myc expression PMID: 18026954
- BP1 may be part of a pathway contributing to non-small cell lung cancer (NSCLC) development and/or progression and mRNA level could be a novel prognostic marker for NSCLC. PMID: 18420035
- BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or invasion. PMID: 18931648
- Other mechanisms in addition to gene amplification play a role in BP1 protein expression om breast camcer/ PMID: 18992636
- High BP1 expression is associated with inflammatory breast cancer and tumor aggressiveness PMID: 19242057
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相關疾病：Non-syndromic orofacial cleft 15 (OFC15)
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亞細胞定位：Nucleus.
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蛋白家族：Distal-less homeobox family
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組織特異性：Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
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數據庫鏈接：
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