DLG1 Antibody, FITC conjugated

說明書

中文名稱：

DLG1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA614264LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DLG1 Polyclonal antibody
Uniprot No.：

Q12959
基因名：

DLG1
別名：

Discs large homolog 1 antibody; discs large; Drosophila; homolog of; 1 antibody; discs; large homolog 1 (Drosophila) antibody; Disks large homolog 1 antibody; dJ1061C18.1.1 antibody; DKFZp761P0818 antibody; DKFZp781B0426 antibody; DLG 1 antibody; DLG1 antibody; DLG1_HUMAN antibody; DLGH 1 antibody; DLGH1 antibody; hDlg antibody; Presynaptic protein SAP97 antibody; SAP 97 antibody; SAP-97 antibody; SAP97 antibody; Synapse associated protein 97 antibody; Synapse-associated protein 97 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Disks large homolog 1 protein (662-773AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane.
基因功能參考文獻：
1. the increased expression of DLG1 may be predictive of an unfavorable prognosis in colorectal cancer. PMID: 29263038
2. By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax. The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC). PMID: 29168728
3. These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity PMID: 28244171
4. Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia. PMID: 28990294
5. Low expression of DLG1 is associated with Crohn's disease. PMID: 27760079
6. BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions. PMID: 28195572
7. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation. PMID: 27026592
8. that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes PMID: 27240320
9. Results suggest that discs large tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information. PMID: 28040505
10. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified. PMID: 26440542
11. Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions. PMID: 26653181
12. The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes. PMID: 25720117
13. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PMID: 25268382
14. the synapse-associated protein-97 (SAP97), an excitatory synapse scaffolding element, governs ADAM10 trafficking from dendritic Golgi outposts to synaptic membranes, mediated by a previously uncharacterized protein kinase C. PMID: 25429624
15. E4-ORF1 interacts with Dlg1 and PI3K to assemble a ternary complex where E4-ORF1 hijacks the Dlg1 oncogenic function to relocate cytoplasmic PI3K to the membrane for constitutive activation. PMID: 24788832
16. While other domains of SAP97 were involved in forward trafficking of GluN1-3 out of the endoplasmic reticulum (ER), the SH3 domain was necessary and sufficient to block the ER retention. PMID: 25499266
17. DLG1, XIST, DDX3Y and RPS4Y1 genes can classify samples into different group clearly, and they are regarded as high confidence distinct gene biomarkers of Parkinson disease. PMID: 25275262
18. Novel genetic variants in the coding regions of DLG1 gene associated with susceptibility to Crohn's disease. PMID: 24937328
19. These findings indicate that most, if not all, human adenovirus E4-ORF1 proteins share a conserved molecular mechanism of PI3K activation via Dlg1 binding and confer a common capacity to promote oncogenic transformation. PMID: 25253337
20. MPP3 and Dlg, membrane-associated guanylate kinase homologs (MAGuK) proteins, connect CADM1 with p85 of PI3K by forming a multi-protein complex at the periphery of cells. PMID: 24503895
21. SAP97 plays a conserved role in regulating 5-HT2AR endocytosis and ERK1/2 signaling, but plays a novel role in regulating 5-HT2AR G protein coupling. PMID: 24989932
22. the nature of the residue at position -3 in the PDZ regulated whether the beta1-AR was internalized alone or in complex with SAP97. PMID: 24324269
23. our findings suggest a molecular mechanism by which CASK binding regulates SAP97 conformation and its subsequent sorting and synaptic targeting of AMPARs and NMDARs during trafficking to synapses. PMID: 23864692
24. The C-terminal tail of DLG1 is bound to the peptide-binding site of an adjacent symmetry-related DLG1 guanylate kinase molecule. PMID: 23624197
25. Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells. PMID: 23532850
26. During anoikis, hScrib and hDlg1 have distinct and opposing functions in human keratinocytes. PMID: 22792261
27. Dlg is a physiologically relevant regulator of Cx43 in transformed epithelial cells. PMID: 22657348
28. Data suggest that hDlg may serve as a platform to bring in proximity APC and PTEN tumor suppressor activities. PMID: 22434720
29. Mutations in the coding sequence of LAMC1 and DLGH1 may not be associated with Mayer-Rokitansky-Kuster-Hauser Syndrome. PMID: 22377151
30. Knockdown of Dlg1, which binds Kv1.3 channels to tyrosine kinase Lck, abolishes modulation of Kv1.3 channels. PMID: 22378744
31. Dlg1 has a distinct oncogenic function in the context of HPV induced malignancy, one of the outcomes of which is increased RhoG activity and increased invasive capacity. PMID: 22383878
32. Data suggest that the effect of Dlg1 on HIV-1 infectivity is at the stage of virus entry. PMID: 22272285
33. These findings further support the possible involvement of the SAP97 gene variation in the susceptibility to schizophrenia in males and in the genetic basis for sex differences in the disorder PMID: 22225629
34. E-cadherin is necessary for localization of DLG1 but not phosphorylated MEK2 to the midbody ring during cytokinesis. PMID: 22185284
35. These findings not only indicate SAP97 as a point of convergence between amyloid cascade and synaptic failure in AD, but also allow a different interpretation of AD which can be now perceived as synaptic trafficking defect pathology. PMID: 20980075
36. Dlgh1 operates independently of the negative feedback pathway mediated by the related adapter protein Carma1 and thus presents an array of unique targets to selectively manipulate Treg function PMID: 22307621
37. Data establish the requirement of scaffolding to DLG1 for PKCalpha to promote cellular migration. PMID: 22027822
38. Results provide new insights into the binding mode of a defined C-terminal segment of APC by the PDZ domains of DLG1. PMID: 21858148
39. Low-to-moderate penetrance protein coding mutations or non-coding mutations at DLG1 and/or PAK2, or a nearby gene, may reproduce the behavioral characteristics of the 3q29 microdeletion. PMID: 21850710
40. These findings indicate that binding of NS1 to Scribble and Dlg1 functions to disrupt the cellular tight junction and that this effect likely contributes to the severe disease associated with highly pathogenic H5N1 influenza A viruses. PMID: 21849460
41. hDlg acts as a MEK2-specific scaffold protein for the ERK signaling pathway. PMID: 21615688
42. Studies represent first analyses of 5'-UTR of DLG1 transcripts; data suggest that differential expression of alternatively spliced 5'-UTRs with different translational properties result in changes in DLG1 expression. PMID: 21595829
43. HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. PMID: 21489588
44. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. PMID: 21164104
45. the higher off rate constants of HPV16 E6, as compared with those of the HPV18 E6 mimic E6L151V, account for its lower affinity toward the SAP97 PDZ domains, in particular for PDZ2 and PDZ3 PMID: 21113079
46. In response to hyperosmotic stress, p38 also regulates formation of complexes between hDlg and PSF. PMID: 20605917
47. The Dlg1-MPP7-Mals3 heterotrimer consists of 2 pairs of heterodimeric L27 domains. These 2 dimers are asymmetric due to the large difference between the N- and C-terminal tandem L27 domain of MPP7. PMID: 20702775
48. The Dlg1 interacts with dynein via the scaffolding protein GKAP and together, Dlg1, GKAP, and dynein control microtubule dynamics and organization near the cell cortex and promote centrosome positioning. PMID: 21041448
49. these results reveal a previously unreported pathway for hDlg phosphorylation in mitosis and show that ERK5 pathway mediates hDlg cell cycle dependent phosphorylation. PMID: 20643107
50. These results uncover a crucial function for ezrin, Dlg1 and microtubules in the organization of the immune synapse and TCR signal down-regulation. PMID: 20551903
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亞細胞定位：

Membrane; Peripheral membrane protein. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell membrane, sarcolemma. Apical cell membrane. Cell junction. Cytoplasm.
蛋白家族：

MAGUK family
組織特異性：

Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level). Widely expressed, with isoforms displaying different expression pro
數據庫鏈接：

HGNC: 2900

OMIM: 601014

KEGG: hsa:1739

STRING: 9606.ENSP00000345731

UniGene: Hs.292549

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