DIO3 Antibody
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中文名稱：DIO3兔多克隆抗體
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貨號：CSB-PA211042
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規格：￥1090
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圖片：
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Western Blot analysis of HuvEc cells using DIO3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：DIO3
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別名：5DIII antibody; D3 antibody; Deiodinase iodothyronine type 3 antibody; Deiodinase iodothyronine type III antibody; Dio 3 antibody; Dio3 antibody; DIOIII antibody; IOD3_HUMAN antibody; Iodothyronine deiodinase placental type antibody; MGC124117 antibody; MGC124118 antibody; Thyroxine deiodinase type III antibody; Thyroxine deiodinase type III (selenoprotein) antibody; TXDI3 antibody; Type 3 DI antibody; Type 3 iodothyronine selenodeiodinase antibody; Type III 5' deiodinase antibody; Type III iodothyronine deiodinase antibody; Type-III 5''-deiodinase antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human DIO3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
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基因功能參考文獻：
- The expression of DIO3 on mRNA/protein levels in the depressive disorders patients was increased in comparison to the control subjects. PMID: 29182613
- The expression of piRNAs encoded at DLK1-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome. PMID: 27829231
- A critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential. PMID: 29186449
- In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele. PMID: 27329732
- Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase system or through modulation of intracellular Thyroid hormone bioavailability. PMID: 27355490
- MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma PMID: 26825960
- D3 is a critical factor in testis development and in testicular protection from thyrotoxicosis. PMID: 26727108
- the microRNA cluster at the Dlk1-Dio3 locus is upregulated in lung adenocarcinoma PMID: 24317514
- [review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone parameters. PMID: 24878678
- Overall, the data suggest that active expression of the DLK1-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs. PMID: 24123616
- the imprinted DLK1-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome PMID: 24816254
- Data indicate that Na+/I- symporter and type 3 iodothyronine deiodinase genes are expressed in term placenta and amniotic membrane. PMID: 23857380
- Treatment with high affinity amyloidbeta42 oligomer-binding enantiomeric D3 peptide significantly decreases amyloidbeta deposits and the associated inflammatory response and improves cognition, even when applied only at late stages and high age. PMID: 23271316
- D3 expression is re-activated in various types of human cancers. It may play a role in carcinogenesis and neoplastic cell proliferation. Review. PMID: 23235188
- Reviewed are the microRNAs within the DLK1-DIO3 genomic region, their role in controlling tissue homeostasis and in the pathogenesis of some human diseases, mostly cancer, when aberrantly expressed. [review] PMID: 22825660
- Deiodinase iodothyronine type III activity was increased in all papillary thyroid carcinomas as compared with that in adjacent thyroid tissue, parallel with ~ 5 times increase in deiodinase iodothyronine type III mRNA levels. PMID: 22823995
- D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone, the absence of which leads to impaired beta-cell function and subsequently insulin secretion and glucose homeostasis PMID: 21828183
- coordinate up-regulation of the DLK1-DIO3 miRNA cluster at 14q32.2 may define a novel molecular (stem cell-like) subtype of hepatocellular carcinoma associated with poor prognosis PMID: 21737452
- [review] progress made in understanding the physiological function and significance of D3; summarizes the intriguing evidence that D3 plays a pivotal role in defining local TH concentration in the developing fetus and in several conditions in adult life. PMID: 21398344
- The minor allele of the DIO3 variant rs945006 showed suggestive evidence for protective association in the overall meta-analyses, which was supported by individual osteoarthritis studies and osteoarthritis subtypes. PMID: 20724312
- In this case-control study, homozygosity for type 2 deiodinase Thr92Ala polymorphism is associated with increased risk for type 2 diabetes. PMID: 20566590
- The expression of D3 mRNA was more than 10 times higher in the tumor tissue than the mean of placental tissues PMID: 19548001
- study demonstrates that D3 is located in the plasma membrane with most of its molecule in the extracellular space, allowing access to inactivate both the hormone T3 and prohormone T4 PMID: 12419801
- the SeC residue in the catalytic center of D3 is essential for efficient inner-ring deiodination of T(3) and in particular T(4) at physiological substrate concentrations. PMID: 12746313
- D3 contains a glycoside hydrolase clan GH-A-like structure PMID: 12847093
- identified a conserved enhancer located 3' of the DIO3 gene containing putative AP-1 and serum response elements, that further increases the serum responsiveness of the Dio3 promoter in a cell-specific manner PMID: 12943987
- TGF-beta stimulates transcription of the hDio3 gene via a Smad-dependent pathway. PMID: 16037131
- structure and function of the type 3 deiodinase gene [review] PMID: 16131329
- postnatal expression of Dio3 can be reactivated in normal tissues during critical illness and other pathologic conditions [review] PMID: 16131330
- Deiodinase D3 exists as homo- or heterodimer in living intact cells, a feature that is critical for their catalytic activities. PMID: 18356288
- Prx3 knockdown resulted in a 50% decrease in D3-mediated whole-cell deiodination. PMID: 19819956
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亞細胞定位：Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
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蛋白家族：Iodothyronine deiodinase family
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組織特異性：Expressed in placenta and several fetal tissues.
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