DENND1A Antibody

中文名稱：

DENND1A兔多克隆抗體
貨號：

CSB-PA823472LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA823472LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DENND1A Polyclonal antibody
Uniprot No.：

Q8TEH3
基因名：

DENND1A
別名：

Connecdenn 1 antibody; Connecdenn antibody; DEN1A_HUMAN antibody; DENN domain-containing protein 1A antibody; DENN/MADD domain containing 1A antibody; dennd1a antibody; FAM31A antibody; FLJ21129 antibody; FLJ38464 antibody; KIAA1608 antibody; OTTHUMP00000022090 antibody; Protein FAM31A antibody; RP11 230L22.3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DENN domain-containing protein 1A protein (1-559AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DENND1A Antibody (CSB-PA823472LA01HU)，的標記方式是Non-conjugated。對于DENND1A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA823472LB01HU	DENND1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA823472LC01HU	DENND1A Antibody, FITC conjugated
Biotin	CSB-PA823472LD01HU	DENND1A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P.
基因功能參考文獻：
1. The association of DENND1A rs10818854 and rs10986105 variants with PCOS in Tunisian but not Bahraini women confirms the dependence of this association on the ethnic/racial origin of study subjects. PMID: 29325736
2. Genome-wide association studies have identified DENND1A as a candidate gene for polycystic ovary syndrome (PCOS). PCOS theca cells are shown to overexpress DENND1A splice variant 2 (V2), but not V1. Also, the genetic variation 330 bp upstream of exon 20A is not associated with VE variant expression. PMID: 27297658
3. DENND1A gene variant is likely to have influence on PCOS risk. PMID: 27488699
4. This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of polycystic ovary syndrome PMID: 26757598
5. The guanine nucleotide exchange factor activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt activation downstream of insulin stimulation. PMID: 26055712
6. We demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women. PMID: 25626177
7. sequence analysis of the DENND1A gene of patients with PCOS did not identify alterations that alone could be responsible for the PCOS pathogenesis PMID: 24086769
8. DENND1A, plays a key role in the hyperandrogenemia associated with polycystic ovary syndrome. PMID: 24706793
9. THADA and DENND1A, carry risk alleles that are associated with endocrine and metabolic disturbances in PCOS patients of Han Chinese descent. PMID: 23208300
10. Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. PMID: 22902918
11. The rs2479106 G allele was associated with decreased PCOS susceptibility PMID: 22504079
12. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. PMID: 22547425
13. At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations. PMID: 22180642
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相關疾病：

Genetic variants in DENND1A may play a role in susceptibility to polycystic ovary syndrome (PCOS), the most common endocrine disease among premenopausal women. PCOS is a complex disorder characterized by infertility, hirsutism, obesity, various menstrual disturbances, and enlarged ovaries studded with atretic follicles.
亞細胞定位：

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane.
數據庫鏈接：

HGNC: 29324

OMIM: 613633

KEGG: hsa:57706

STRING: 9606.ENSP00000362727

UniGene: Hs.744995

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